Proteomes · Salmonella newport (strain SL254)

Description

Salmonella species belong to the group of Enterobactericiae. These bacteria were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The majority of the components of these bacteria are identical, and at the DNA level, they are between 95% and 99% identical. Many Salmonella enterica are involved in causing diseases of the intestine (enteric means pertaining to the intestine). The nontyphoidal Salmonella are the leading cause of bacterial food borne illness in humans, making these pathogens an immediate biomedical, public health, and biodefense concern. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria, which then leads to systemic spread. Salmonella newport (strain SL254) is prevalent in many geographic regions. Outbreak investigations and targeted studies have identified dairy cattle as the main reservoir of S. newport. Antimicrobial resistance (Newport MDR-AmpC) is particularly problematic in this serotype, where the prevalence of Newport MDR-AmpC among S. newport isolates from humans in the United States increased from 0% during 1996-1997 to 26% in 2001. MDR strains of S. newport have been recorded as resistant to ampicillin, chloramphenicol, streptomycin, sulphonamides and tetracycline (ACSSuT) and many of these strains show intermediate or full resistance to third-generation cephalosporins, kanamycin, potentiated sulphonamides, and gentamicin. Two distinct evolutionary lineages exist in this serotype; antibiotic susceptible strain SL317 is from one lineage, while MDR strain SL254 is from the other.

Components

Component nameGenome accession(s)Protein count
ChromosomeCP0011134,598
Plasmid pSN254CP000604183
Plasmid pSL254_3CP0011123

Publications

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