Proteomes · Burkholderia mallei (strain NCTC 10229)

Description

Burkholderia mallei is the etiologic agent of glanders, a disease that is often fatal. Its natural reservoir are horses and other equines, but it can be occasionally transmitted to humans either by inhalation or through breaks in the skin. It is an obligate animal pathogen, with an intracellular localization. B. mallei is highly infectious as an aerosol and was used as a biological weapon in the American Civil War and in both World Wars. Unlike the related bacterium B.pseudomallei it is non-motile. One of its virulence factors has been identified as the type III secretion system, another as the newly characterized type VI (T6S). Strain NCTC 10229 will be used for comparative genomics. Comparison of a number of B.mallei and B.pseudomallei strains has shown that B.mallei recently evolved from a single strain of B.pseudomallei upon introduction into an animal host. This was followed by expansion of insertion sequence elements, prophage elimination, genome rearrangements and reduction mediated by homologous recombination across IS elements, processes which are ongoing in different strains and lead to variation in virulence (adapted from PMID 20333227).

Components

Component nameGenome accession(s)Protein count
Chromosome ICP0005463,045
Chromosome IICP0005451,907

Publications

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