Proteomes · Clostridioides difficile (strain CD196) (Peptoclostridium difficile)

Description

Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis. Although two important virulence factors of C. difficile have been shown to be exotoxins, toxin A (TcdA) and toxin B (TcdB), little is known about other factors involved in the adherence and colonization processes. In the past 5 years a new group of highly virulent C. difficile strains has emerged to cause outbreaks of increased disease severity in North America and Europe. Several studies have shown that patients infected with these PCR-ribotype 027 strains have more severe diarrhea, higher mortality and more recurrences. The earliest recorded PCR-ribotype 027 isolate was strain CD196, which is a non-epidemic strain isolated from a single patient with CDI in a Paris hospital in 1985. PCR-ribotype 027 strains are genetically highly uniform. This genome was sequenced and subjected to a three-way genome comparison of this non-epidemic 027 C. difficile strain (CD196), a recent epidemic and hypervirulent 027 strain (R20291, CLODR) and the previously published PCR-ribotype 012 strain (630, CLOD6). 027 strains have considerable genetic differences compared to strain 630 that may relate to observed phenotypic differences in motility, survival, antibiotic resistance and toxicity (adapted from PMID 19781061).

Components

Component nameGenome accession(s)Protein count
ChromosomeFN5389703,450

Publications

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