Proteomes · Clostridioides difficile (strain 630) (Peptoclostridium difficile)
- Proteome IDUP000001978
- StatusReference proteome
- Number of entries
- Gene count
- Taxonomy | Strain
- Genome assembly and annotation
- Genome representationFull
- Pan proteomeThis proteome is part of the Clostridioides difficile (strain 630) pan proteome (FASTA)
- Completeness (CPD)Standard
- BUSCOSingleDuplicatedFragmentedMissingn:247 · clostridia_odb10C:99.2% (S:97.6% D:1.6%) F:0% M:0.8%
Description
Clostridioides (formerly Clostridium) difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis. Although two important virulence factors of C. difficile have been shown to be exotoxins, toxin A (TcdA) and toxin B (TcdB), little is known about other factors involved in the adherence and colonization processes.Recently a new group of highly virulent C. difficile strains has emerged to cause outbreaks of increased disease severity in North America and Europe. Several studies have shown that patients infected with these PCR-ribotype 027 strains have more severe diarrhea, higher mortality and more recurrences.
Strain 630 (epidemic type X, PCR-ribotype 012) is a virulent and multidrug-resistant strain, and was isolated from a hospital patient with severe pseudomembraneous colitis, which had spread to several other patients on the same ward. It has several copies of a chimaeric genetic element comprising a group I intron and insertion element (an IStron). Where an IStron is inserted in an expressed gene it is probably precisely excised so that the gene remains functional.