Cellular component - Endoplasmic reticulum
- DefinitionThe endoplasmic reticulum (ER) is an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products. The membrane is a continuation of the outer nuclear membrane, it encloses the cytosol cisternal spaces (or internal lumen), which are continuous with the nuclear periplasmic space. The ER sustains many general functions, including protein synthesis, protein modification, protein folding, insertion of membrane proteins, sequestration of calcium, production of phospholipids and steroids and transport of proteins destined for membranes and secretion.
- CategoryCellular component
- Gene Ontology (GO)
- ContentEndoplasmic reticulum
- Keyword
- NoteCompartment specific marker: PDI; calreticulin; calnexin.
Related UniProtKB entries
Browse all 1,146,386 entries- Glycine N-acyltransferase-like protein 2 · Gene: GLYATL2 · Homo sapiens (Human) · EC:2.3.1.13 · 294 amino acids · Evidence at protein level · Annotation score: 5/5
- Dehydrogenase/reductase SDR family member 1 · Gene: DHRS1 (SDR19C1) · Homo sapiens (Human) · EC:1.1.1.- · 313 amino acids · Evidence at protein level · Annotation score: 5/5
- Dolichol-phosphate mannosyltransferase subunit 1 · Gene: DPM1 · Homo sapiens (Human) · EC:2.4.1.83 · 260 amino acids · Evidence at protein level · Annotation score: 5/5
- LRP chaperone MESD · Gene: MESD (KIAA0081, MESDC2, MESDM) · Homo sapiens (Human) · 234 amino acids · Evidence at protein level · Annotation score: 5/5
- EPM2A-interacting protein 1 · Gene: EPM2AIP1 (KIAA0766) · Homo sapiens (Human) · 607 amino acids · Evidence at protein level · Annotation score: 5/5
- GDP-fucose protein O-fucosyltransferase 1 · Gene: POFUT1 (FUT12, KIAA0180) · Homo sapiens (Human) · EC:2.4.1.221 · 388 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein canopy homolog 2 · Gene: CNPY2 (MSAP, TMEM4, ZSIG9) · Homo sapiens (Human) · 182 amino acids · Evidence at protein level · Annotation score: 5/5
- Immunoglobulin iota chain · Gene: VPREB1 (VPREB) · Homo sapiens (Human) · 145 amino acids · Evidence at protein level · Annotation score: 5/5
- Glucosidase 2 subunit beta · Gene: PRKCSH (G19P1) · Homo sapiens (Human) · 528 amino acids · Evidence at protein level · Annotation score: 5/5
- DnaJ homolog subfamily C member 3 · Gene: DNAJC3 (P58IPK, PRKRI) · Homo sapiens (Human) · 504 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein disulfide isomerase CRELD2 · Gene: CRELD2 · Homo sapiens (Human) · EC:5.3.4.1 · 353 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein canopy homolog 3 · Gene: CNPY3 (CTG4A, ERDA5, PRAT4A, TNRC5) · Homo sapiens (Human) · 278 amino acids · Evidence at protein level · Annotation score: 5/5
- Peptidyl-prolyl cis-trans isomerase FKBP9 · Gene: FKBP9 (FKBP60, FKBP63) · Homo sapiens (Human) · EC:5.2.1.8 · 570 amino acids · Evidence at protein level · Annotation score: 5/5
- Alpha-1-antitrypsin-related protein · Gene: SERPINA2 (ARGS, ATR, PIL, SERPINA2P) · Homo sapiens (Human) · 421 amino acids · Evidence at protein level · Annotation score: 5/5
- Cathepsin W · Gene: CTSW · Homo sapiens (Human) · EC:3.4.22.- · 376 amino acids · Evidence at protein level · Annotation score: 5/5
- Neurobeachin-like protein 2 · Gene: NBEAL2 (KIAA0540) · Homo sapiens (Human) · 2754 amino acids · Evidence at protein level · Annotation score: 5/5
- Prolyl 3-hydroxylase 3 · Gene: P3H3 (LEPREL2) · Homo sapiens (Human) · EC:1.14.11.7 · 736 amino acids · Evidence at protein level · Annotation score: 5/5
- Anterior gradient protein 3 · Gene: AGR3 (BCMP11, PDIA18) · Homo sapiens (Human) · 166 amino acids · Evidence at protein level · Annotation score: 5/5
- Ankyrin repeat and SOCS box protein 11 · Gene: ASB11 · Homo sapiens (Human) · 323 amino acids · Evidence at protein level · Annotation score: 5/5
- 17-beta-hydroxysteroid dehydrogenase type 3 · Gene: HSD17B3 (EDH17B3, SDR12C2) · Homo sapiens (Human) · 310 amino acids · Evidence at protein level · Annotation score: 5/5
- Deoxyribonuclease-1-like 1 · Gene: DNASE1L1 (DNAS1L1, DNL1L) · Homo sapiens (Human) · EC:3.1.21.- · 302 amino acids · Evidence at protein level · Annotation score: 5/5
- Cytochrome b5 reductase 4 · Gene: CYB5R4 (NCB5OR) · Homo sapiens (Human) · EC:1.6.2.2 · 521 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein disulfide-isomerase-like protein of the testis · Gene: PDILT · Homo sapiens (Human) · 584 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein TFG · Gene: TFG · Homo sapiens (Human) · 400 amino acids · Evidence at protein level · Annotation score: 5/5
- Endoplasmic reticulum protein SC65 · Gene: P3H4 (LEPREL4, NOL55, SC65) · Homo sapiens (Human) · 437 amino acids · Evidence at protein level · Annotation score: 5/5