Keywords - Evasion of bacteria-mediated translation shutoff by virus (KW-1259)
- DefinitionViral protein that counteracts the translation shutoff set up by the bacterial host in order to inhibit viral replication. This antiviral defense system alters a crucial cellular process thereby blocking virus multiplication and ending up with host dormancy or even cell death. For example, some E.coli strains infected by bacteriophage T4 activate an anticodon nuclease which causes depletion of tRNA(Lys) and, consequently, abolishes T4 protein synthesis and causes cell death. However, this effect is counteracted by the repair of tRNA(Lys) in consecutive reactions catalyzed by the viral enzymes polynucleotide kinase and RNA ligase. The ToxIN system functions as a toxin-antitoxin (TA) tandem which is used as a antiviral defense mechanism.
- Category
- Gene Ontology (GO)
- Ancestors
- Graphical
Related UniProtKB entries
Browse all 584 entries- RNA ligase 1 · Gene: 63 · Enterobacteria phage T4 (Bacteriophage T4) · EC:6.5.1.3 · 374 amino acids · Evidence at protein level · Annotation score: 5/5
- Polynucleotide kinase · Gene: pseT · Enterobacteria phage T4 (Bacteriophage T4) · EC:2.7.1.78 · 301 amino acids · Evidence at protein level · Annotation score: 4/5
- Antitoxin Dmd · Gene: dmd (61.5, y02B) · Enterobacteria phage T4 (Bacteriophage T4) · 60 amino acids · Evidence at protein level · Annotation score: 3/5
- RNA ligase · Rhodothermus phage RM378 (Bacteriophage RM378) · EC:6.5.1.- · 438 amino acids · Evidence at protein level · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Enterobacteria phage RB3 (Bacteriophage RB3) · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage vb_EcoM-VR5 · EC:6.5.1.3 · 382 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage UFV-AREG1 · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage ime09 · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Aeromonas phage CC2 · EC:6.5.1.3 · 392 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Aeromonas phage Aes012 · EC:6.5.1.3 · 383 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Stenotrophomonas phage IME13 · EC:6.5.1.3 · 384 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Aeromonas phage Aes508 · EC:6.5.1.3 · 383 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Aeromonas phage 31 · EC:6.5.1.3 · 383 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Aeromonas phage 44RR2.8t · EC:6.5.1.3 · 383 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage RB69 (Bacteriophage RB69) · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Vibrio phage nt-1 · EC:6.5.1.3 · 379 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Yersinia phage PST · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Enterobacteria phage GEC-3S · EC:6.5.1.3 · 389 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Enterobacteria phage RB51 (Bacteriophage RB51) · EC:6.5.1.3 · 374 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage JSE · EC:6.5.1.3 · 394 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage JS10 · EC:6.5.1.3 · 382 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Enterobacter phage CC31 · EC:6.5.1.3 · 368 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage vB_EcoM_VR7 · EC:6.5.1.3 · 378 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage Lw1 · EC:6.5.1.3 · 385 amino acids · Inferred from homology · Annotation score: 3/5
- RNA ligase 1 · Gene: rnlA · Escherichia phage vB_EcoM_VR20 · EC:6.5.1.3 · 378 amino acids · Inferred from homology · Annotation score: 3/5