Keywords - Clathrin- and caveolin-independent endocytosis of virus by host (KW-1167)
- DefinitionViral protein involved in virus internalization into the host cell via endocytic pathways that involve neither clathrin nor caveolins. These pathways can be further defined by their dependency on various molecules such as cholesterol, DNM2/Dynamin-2, small GTPases or tyrosine kinase and possibly involve non-caveolar lipid rafts. Clathrin- and caveolin-independent pathways are used by viruses including poliovirus, human rhinovirus 14, lymphocytic choriomeningitis virus, murine norovirus-1 and SV40.
- Synonyms
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalClathrin- and caveolin-independent endocytosis of virus by host
Related UniProtKB entries
Browse all 133,603 entries- Genome polyprotein · Foot-and-mouth disease virus (isolate -/Germany/A5Westerwald/1951 serotype A) (FMDV) · 2332 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Aichi/2/1968 H3N2) · 566 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Japan/305/1957 H2N2) · 562 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 3 (strain 23127) · 2206 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Duck/Ireland/113/1983 H5N8) · 566 amino acids · Inferred from homology · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B) · 2206 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Caveolin-mediated endocytosis of virus by host #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Foot-and-mouth disease virus serotype O (FMDV) · 2332 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Foot-and-mouth disease virus (isolate Bovine/Brazil/A24Cruzeiro/1955 serotype A) (FMDV) · 2333 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2)) · 566 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Foot-and-mouth disease virus (isolate -/Germany/C1Oberbayen/1960 serotype C) (FMDV) · 2327 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4) · 564 amino acids · Inferred from homology · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Capsid protein · Gene: Cap · Porcine circovirus 2 (PCV2) · 233 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Foot-and-mouth disease virus (isolate -/Brazil/C3Indaial/1971 serotype C) (FMDV) · 2328 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Victoria/3/1975 H3N2) · 567 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) · 565 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 2 (strain W-2) · 2205 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Foot-and-mouth disease virus (isolate -/Spain/S8c1SantaPau/1970 serotype C) (FMDV) · 2327 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Host-virus interaction #Ion transport #Modulation of host chromatin by virus #Translation regulation #Transport #Viral attachment to host cell #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1) · 563 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 1 (strain Sabin) · 2209 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) · 565 amino acids · Evidence at protein level · Annotation score: 5/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 2 (strain Lansing) · 2207 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Chile/1/1983 H1N1) · 566 amino acids · Inferred from homology · Annotation score: 4/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/India/6263/1980 H1N1) · 566 amino acids · Inferred from homology · Annotation score: 4/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd) · 568 amino acids · Evidence at transcript level · Annotation score: 4/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Hemagglutinin · Gene: HA · Influenza A virus (strain A/Duck/New York/12/1978 H11N6) · 100 amino acids · Inferred from homology · Annotation score: 4/5#Hemagglutinin #Clathrin- and caveolin-independent endocytosis of virus by host #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Viral attachment to host cell #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell