Keywords - Modulation of host ubiquitin pathway by viral deubiquitinase (KW-1127)
- DefinitionViral protein possessing deubiquitinating activity. Hijacking the ubiquitin system plays an essential role during viral replication. Therefore, several viruses including EBV or HCMV encode for proteins able to remove ubiquitin or ubiquitin-like proteins from their substrate.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalModulation of host ubiquitin pathway by viral deubiquitinase
Related UniProtKB entries
Browse all 8,211 entries- Replicase polyprotein 1a · Gene: 1a · Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) · 4128 amino acids · Inferred from homology · Annotation score: 5/5#Hydrolase #Protease #RNA-binding #Thiol protease #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3) · 4376 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus HKU1 (isolate N2) (HCoV-HKU1) · 4441 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus OC43 (HCoV-OC43) · 4383 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1ab · Gene: rep · Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) · 7182 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1ab · Gene: rep · Human coronavirus HKU1 (isolate N2) (HCoV-HKU1) · 7152 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1a · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 4405 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1ab · Gene: rep · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 7096 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Inhibition of host RLR pathway by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Non-structural replication polyprotein · Turnip yellow mosaic virus (isolate TYMC) · 1844 amino acids · Inferred from homology · Annotation score: 5/5#Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-directed RNA polymerase #Thiol protease #Transferase #Host-virus interaction #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Viral RNA replication
- RNA-directed RNA polymerase L · Gene: L · Dugbe virus (isolate ArD44313) (DUGV) · 4036 amino acids · Evidence at protein level · Annotation score: 5/5#Hydrolase #Nucleotidyltransferase #RNA-directed RNA polymerase #Transferase #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Viral immunoevasion #Viral RNA replication
- RNA-directed RNA polymerase L · Gene: L · Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) · 3945 amino acids · Evidence at protein level · Annotation score: 5/5#Hydrolase #Nucleotidyltransferase #RNA-directed RNA polymerase #Transferase #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1a · Gene: 1a · Bovine coronavirus (strain Quebec) (BCoV) (BCV) · 4383 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus 229E (HCoV-229E) · 4085 amino acids · Evidence at protein level · Annotation score: 5/5#Hydrolase #Protease #RNA-binding #Thiol protease #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) · 4416 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) · 4468 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1ab · Gene: rep · Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3) · 7067 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1ab · Gene: rep · Bovine coronavirus (strain Mebus) (BCoV) (BCV) · 7094 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1ab · Gene: rep · Porcine epidemic diarrhea virus (strain CV777) (PEDV) · 6781 amino acids · Evidence at protein level · Annotation score: 5/5#DNA-binding #Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1ab · Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV) · 3838 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Helicase #Hydrolase #Lyase #Multifunctional enzyme #Nuclease #Nucleotidyltransferase #Protease #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Inhibition of host PKR by virus #Inhibition of host STAT1 by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Viral immunoevasion #Viral RNA replication
- Replicase polyprotein 1a · Gene: 1a · Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005) · 4388 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV) · 4383 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV) · 4383 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) · 4471 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus NL63 (HCoV-NL63) · 4060 amino acids · Evidence at protein level · Annotation score: 5/5#Hydrolase #Protease #RNA-binding #Thiol protease #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) · 4017 amino acids · Evidence at protein level · Annotation score: 5/5#Hydrolase #Protease #RNA-binding #Thiol protease #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion