Keywords - Inhibition of host RLR pathway by virus (KW-1113)
- DefinitionViral protein involved in the evasion of host innate defense by inhibiting the DDX58/RIG-I-like receptor (RLR) pathway leading to the triggering of interferon-mediated response. This pathway starts with the recognition of viral RNA by host proteins including DDX58/RIG-I or IFIH1. Then, the signal is transmitted through MAVS and TRAFs leading to the activation and nuclear localization of transcription factors IRF3 and IRF7 to induce IFNalpha/beta transcription and protein production. Many viruses interact with components of this pathway to inhibit production of interferons and establishment of the antiviral state.
- Category
- Gene Ontology (GO)
- Descendants
- Ancestors
- GraphicalInhibition of host RLR pathway by virus
Related UniProtKB entries
Browse all 116,779 entries- Genome polyprotein · Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A virus (isolate Human/China/H2/1982)) · 2227 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Ion transport #Transport #Viral attachment to host cell #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- Protein ORF45 · Gene: ORF45 · Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) · 407 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Hepatitis C virus genotype 6a (isolate EUHK2) (HCV) · 3018 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 4a (isolate ED43) (HCV) · 3008 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Porcine enterovirus 9 (strain UKG/410/73) · 2168 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1) · 2184 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Caveolin-mediated endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Hepatitis C virus genotype 1b (strain HC-J4) (HCV) · 3010 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Coxsackievirus B3 (strain Nancy) · 2185 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Poliovirus type 3 (strain 23127) · 2206 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin- and caveolin-independent endocytosis of virus by host #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of eukaryotic host transcription initiation by virus #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Protein E6 · Gene: E6 · Human papillomavirus type 18 · 158 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Coxsackievirus B4 (strain JVB / Benschoten / New York/51) · 2183 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #DNA replication #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host mRNA nuclear export by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Ion transport #Pore-mediated penetration of viral genome into host cell #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Replicase polyprotein 1a · Gene: 1a · Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) · 4128 amino acids · Inferred from homology · Annotation score: 5/5#Hydrolase #Protease #RNA-binding #Thiol protease #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3) · 4376 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus HKU1 (isolate N2) (HCoV-HKU1) · 4441 amino acids · Inferred from homology · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Gene: 1a · Human coronavirus OC43 (HCoV-OC43) · 4383 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1a · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 4405 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Hydrolase #Methyltransferase #Nuclease #Protease #RNA-binding #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion
- Replicase polyprotein 1ab · Gene: rep · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 7096 amino acids · Evidence at protein level · Annotation score: 5/5#Endonuclease #Exonuclease #Helicase #Hydrolase #Lyase #Methyltransferase #Nuclease #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Activation of host autophagy by virus #Decay of host mRNAs by virus #Eukaryotic host gene expression shutoff by virus #Eukaryotic host translation shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host ISG15 by virus #Inhibition of host NF-kappa-B by virus #Inhibition of host RLR pathway by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Modulation of host ubiquitin pathway by viral deubiquitinase #Modulation of host ubiquitin pathway by virus #Ubl conjugation pathway #Viral immunoevasion #Viral RNA replication
- Envelopment polyprotein · Gene: GP · Tula orthohantavirus (TULV) (Tula virus) · 1141 amino acids · Evidence at protein level · Annotation score: 5/5#Activation of host autophagy by virus #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host TRAFs by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Serine/threonine-protein kinase BGLF4 · Gene: BGLF4 · Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) · EC:2.7.11.1 · 429 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus) · 3898 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Nuclease #Nucleotidyltransferase #Protease #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host RLR pathway by virus #Ion transport #Transport #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus entry into host cell
- RNA-binding protein OPG065 · Gene: OPG065 · Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) · 190 amino acids · Evidence at protein level · Annotation score: 5/5#RNA-binding #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host IRF3 by virus #Inhibition of host IRF7 by virus #Inhibition of host ISG15 by virus #Inhibition of host PKR by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Modulation of host cell apoptosis by virus #Viral immunoevasion
- Nucleoprotein · Gene: N · Bovine respiratory syncytial virus (strain A51908) (BRS) · 391 amino acids · Evidence at protein level · Annotation score: 5/5#Ribonucleoprotein #RNA-binding #Viral nucleoprotein #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host MDA5 by virus #Inhibition of host NF-kappa-B by virus #Inhibition of host PKR by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Genome polyprotein · Hepatitis C virus genotype 2a (isolate HC-J6) (HCV) · 3033 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 2b (isolate HC-J8) (HCV) · 3033 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3) · 3390 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell