Keywords - Inhibition of host STAT2 by virus (KW-1106)
- DefinitionViral protein involved in the evasion of type I and III interferon pathways by inhibiting STAT2 protein. Upon viral infection, STAT2 is activated by IFN-alpha/beta or IFN-lambda that bind to specific cell surface receptors. In turn, IFN-alpha/beta (or IFN-lambda) induces heterodimerization of STAT1 and STAT2 by phosphorylation, leading to STAT2 nuclear localization and subsequent induction of IFN-stimulated genes. Many viruses interfere with STAT2 activation, often by preventing STAT2 phosphorylation and nuclear localization.
- Category
- Gene Ontology (GO)
- Ancestors
Related UniProtKB entries
Browse all 13,581 entries- Genome polyprotein · Banzi virus (BANV) · 3393 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus entry into host cell
- Genome polyprotein · Edge Hill virus (EHV) · 3401 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus entry into host cell
- Phosphoprotein · Gene: P · Rabies virus (strain PM1503/AVO1) (RABV) · 297 amino acids · Evidence at protein level · Annotation score: 5/5#Chaperone #Cytoplasmic inwards viral transport #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Microtubular inwards viral transport #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- Phosphoprotein · Gene: P · Rabies virus (strain CVS-11) (RABV) · 297 amino acids · Evidence at protein level · Annotation score: 5/5#Chaperone #Cytoplasmic inwards viral transport #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Microtubular inwards viral transport #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- Genome polyprotein · Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3) · 3390 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Tick-borne encephalitis virus (strain Hypr) (TBEV) · 3414 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Tick-borne powassan virus (strain LB) (POWV) (Powassan virus) · 3415 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV) · 3412 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4) · 3387 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Ilheus virus (ILHV) · 3424 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Non-structural protein V · Gene: P/V/C · Nipah virus · 456 amino acids · Evidence at protein level · Annotation score: 5/5#Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MDA5 by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #Viral immunoevasion
- Genome polyprotein · Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV) · 3411 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Non-structural protein NS-S · Gene: NSS · SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) · 293 amino acids · Evidence at protein level · Annotation score: 5/5#Host G2/M cell cycle arrest by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion
- Phosphoprotein · Gene: P · Rabies virus (strain India) (RABV) · 297 amino acids · Inferred from homology · Annotation score: 5/5#Chaperone #Cytoplasmic inwards viral transport #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Microtubular inwards viral transport #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- C' protein · Gene: P/V/C · Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) · 215 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2) · 3391 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4) · 3387 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2) · 3391 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Japanese encephalitis virus (strain SA(v)) (JEV) · 3432 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Japanese encephalitis virus (strain SA-14) (JEV) · 3432 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Langat virus (strain TP21) · 3414 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Activation of host autophagy by virus #Activation of host caspases by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Modulation of host cell apoptosis by virus #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2) · 3391 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell
- Genome polyprotein · Mosquito cell fusing agent (CFA flavivirus) · 3341 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Nucleotidyltransferase #RNA-binding #RNA-directed RNA polymerase #Transferase #Activation of host autophagy by virus #Host-virus interaction #Inhibition of host complement factors by virus #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Viral attachment to host cell #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- Phosphoprotein · Gene: P · Rabies virus (strain PM) (RABV) · 297 amino acids · Inferred from homology · Annotation score: 5/5#Chaperone #Cytoplasmic inwards viral transport #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host STAT2 by virus #Inhibition of host TBK1 by virus #Inhibition of host TLR pathway by virus #Interferon antiviral system evasion #Microtubular inwards viral transport #Viral immunoevasion #Viral RNA replication #Virus entry into host cell
- Genome polyprotein · Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4) · 3387 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Serine protease #Transferase #Viral ion channel #Activation of host autophagy by virus #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT2 by virus #Inhibition of host TYK2 by virus #Interferon antiviral system evasion #Ion transport #mRNA capping #mRNA processing #Suppressor of RNA silencing #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell