Keywords - Inhibition of host RNA polymerase II by virus (KW-1104)
- DefinitionViral protein involved in the disruption of the host RNA polymerase II. Many viruses induce alterations in the cellular gene expression. Among these, shutoff of host transcription by targeting RNA polymerase II is commonly used. Indeed, many viruses are able to modify RNAP II CTD including Herpes virus, HIV, Epstein-Barr virus or Bunyamwera virus.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalInhibition of host RNA polymerase II by virus
Related UniProtKB entries
Browse all 195,885 entries- Polymerase acidic protein · Gene: PA · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) · EC:3.1.-.- · 716 amino acids · Evidence at protein level · Annotation score: 5/5
- Transcriptional regulator ICP22 · Gene: ICP22 · Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) · 420 amino acids · Evidence at protein level · Annotation score: 5/5
- Polyprotein P1234 · Barmah forest virus (BFV) · 2411 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Eastern equine encephalitis virus (strain PE-0.0155) (EEEV) (Eastern equine encephalomyelitis virus) · 2471 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Eastern equine encephalitis virus (strain PE-3.0815) (EEEV) (Eastern equine encephalomyelitis virus) · 2474 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Eastern equine encephalitis virus (strain Florida 91-469) (EEEV) (Eastern equine encephalomyelitis virus) · 2494 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Getah virus (GETV) · 2467 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Chikungunya virus (strain S27-African prototype) (CHIKV) · 2474 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host RNA polymerase II by virus #Inhibition of host STAT1 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Viral immunoevasion #Viral RNA replication
- Polyprotein P1234 · Sleeping disease virus (SDV) · 2593 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- RNA-directed RNA polymerase catalytic subunit · Gene: PB1 · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) · EC:2.7.7.48 · 757 amino acids · Evidence at protein level · Annotation score: 5/5#Nucleotidyltransferase #RNA-directed RNA polymerase #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #Viral RNA replication #Viral transcription
- Polyprotein P1234 · Semliki forest virus (SFV) · 2432 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host RNA polymerase II by virus #Inhibition of host STAT1 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Viral immunoevasion #Viral RNA replication
- Polyprotein P1234 · O'nyong-nyong virus (strain Gulu) (ONNV) · 2514 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · O'nyong-nyong virus (strain SG650) (ONNV) · 2513 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · O'nyong-nyong virus (strain Igbo Ora) (ONNV) (Igbo Ora virus) · 2513 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polymerase basic protein 2 · Gene: PB2 · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) · 759 amino acids · Evidence at protein level · Annotation score: 5/5#Cap snatching #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral immunoevasion #Viral transcription
- Polymerase basic protein 2 · Gene: PB2 · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) · 759 amino acids · Evidence at protein level · Annotation score: 5/5#Cap snatching #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral immunoevasion #Viral transcription
- Polyprotein P1234 · Ross river virus (strain NB5092) (RRV) · 2480 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Western equine encephalitis virus (WEEV) · 2467 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Venezuelan equine encephalitis virus (strain P676) (VEEV) · 2493 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Sindbis virus (SINV) · 2513 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host RNA polymerase II by virus #Inhibition of host STAT1 by virus #Interferon antiviral system evasion #mRNA capping #mRNA processing #Viral immunoevasion #Viral RNA replication
- RNA-directed RNA polymerase catalytic subunit · Gene: PB1 · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) · EC:2.7.7.48 · 757 amino acids · Evidence at protein level · Annotation score: 5/5#Nucleotidyltransferase #RNA-directed RNA polymerase #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #Viral RNA replication #Viral transcription
- Polyprotein P1234 · Sindbis virus subtype Ockelbo (strain Edsbyn 82-5) (OCKV) (Ockelbo virus) · 2515 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Chikungunya virus (strain 37997) (CHIKV) · 2474 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Mayaro virus (strain Brazil) (MAYV) · 2437 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication
- Polyprotein P1234 · Venezuelan equine encephalitis virus (strain CPA201) (VEEV) · 2497 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Methyltransferase #Multifunctional enzyme #Nucleotidyltransferase #Protease #RNA-binding #RNA-directed RNA polymerase #Thiol protease #Transferase #Eukaryotic host gene expression shutoff by virus #Eukaryotic host transcription shutoff by virus #Host gene expression shutoff by virus #Host-virus interaction #Inhibition of host RNA polymerase II by virus #mRNA capping #mRNA processing #Viral RNA replication