Keywords - Inhibition of host pre-mRNA processing by virus (KW-1103)
- DefinitionViral protein involved in the disruption of host pre-mRNA processing. Viruses have evolved ways of interacting with the cellular RNA splicing machinery and regulate splicing of cellular pre-mRNAs as a part of the mechanism for shutting down the synthesis of host proteins. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalInhibition of host pre-mRNA processing by virus
Related UniProtKB entries
Browse all 57,822 entries- mRNA export factor · Gene: UL54 · Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) · 512 amino acids · Evidence at protein level · Annotation score: 5/5#Activator #RNA-binding #Activation of host NF-kappa-B by virus #Eukaryotic host gene expression shutoff by virus #G1/S host cell cycle checkpoint dysregulation by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RLR pathway by virus #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Udorn/307/1972 H3N2) · 237 amino acids · Evidence at protein level · Annotation score: 5/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) · 230 amino acids · Evidence at protein level · Annotation score: 5/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- mRNA export factor · Gene: UL54 · Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) · 512 amino acids · Evidence at protein level · Annotation score: 5/5#Activator #RNA-binding #Activation of host NF-kappa-B by virus #Eukaryotic host gene expression shutoff by virus #G1/S host cell cycle checkpoint dysregulation by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host pre-mRNA processing by virus #Modulation of host cell cycle by virus #Transcription #Transcription regulation
- Non-structural protein 1 · Gene: NS1 (NS) · Influenza A virus (strain A/Blue-winged teal/Minnesota/993/1980 H6N6) · 230 amino acids · Evidence at protein level · Annotation score: 4/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) · 230 amino acids · Evidence at protein level · Annotation score: 4/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Brazil/11/1978 H1N1) · 237 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Herring gull/DE/677/1988 H2N8) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/USSR/90/1977 H1N1) · 237 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Pintail/Alberta/268/1978 H6N2) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- mRNA export factor · Gene: UL54 · Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1) · 511 amino acids · Evidence at protein level · Annotation score: 3/5#Activator #RNA-binding #Activation of host NF-kappa-B by virus #Eukaryotic host gene expression shutoff by virus #G1/S host cell cycle checkpoint dysregulation by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host pre-mRNA processing by virus #Modulation of host cell cycle by virus #Transcription #Transcription regulation
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Anas acuta/Primorje/695/1976 H2N3) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Leningrad/134/17/1957 H2N2) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Wa-182) · 237 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Duck/Germany/1949 H10N7) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Memphis/101/1972 H3N2) · 220 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Shearwater/Australia/1972 H6N5) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1) · 230 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion
- Non-structural protein 1 · Gene: NS · Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y) · 225 amino acids · Inferred from homology · Annotation score: 3/5#RNA-binding #Eukaryotic host gene expression shutoff by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host PKR by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RIG-I by virus #Inhibition of host RLR pathway by virus #Interferon antiviral system evasion #Viral immunoevasion