Keywords - Inhibition of host tetherin by virus (KW-1084)
- DefinitionViral protein involved in the evasion of host immune defense by inhibiting the BST2/tetherin protein. BST2/tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV- 1), HIV-2, as well as other retroviruses. Several viruses manage to circumvent the antiviral activity of BST2/tetherin either by sending BST2/tetherin to degradation (HIV-1) or by lowering the presence of BST2 on cell surfaces (HIV-2).
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalInhibition of host tetherin by virus
Related UniProtKB entries
Browse all 14,124 entries- Envelope glycoprotein · Gene: GP · Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Protein Vpu · Gene: vpu · Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) · 82 amino acids · Evidence at protein level · Annotation score: 5/5
- Spike glycoprotein · Gene: S · Severe acute respiratory syndrome coronavirus (SARS-CoV) · 1255 amino acids · Evidence at protein level · Annotation score: 5/5#Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virulence #Virus entry into host cell
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2) · 857 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein · Gene: GP · Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2) · 738 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein · Gene: GP · Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus) · 676 amino acids · Inferred from homology · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein · Gene: GP · Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) · 677 amino acids · Inferred from homology · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2) · 857 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2) · 856 amino acids · Evidence at protein level · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2) · 846 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2) · 859 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2) · 859 amino acids · Evidence at protein level · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2) · 859 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Envelope glycoprotein · Gene: GP · Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein · Gene: GP · Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein · Gene: GP · Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein · Gene: GP · Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus) · 676 amino acids · Evidence at protein level · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein · Gene: GP · Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus) · 677 amino acids · Inferred from homology · Annotation score: 5/5#Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral attachment to host entry receptor #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) · 858 amino acids · Evidence at protein level · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Protein Vpu · Gene: vpu · Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) · 81 amino acids · Evidence at protein level · Annotation score: 5/5
- Spike glycoprotein · Gene: S · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 1273 amino acids · Evidence at protein level · Annotation score: 5/5#Superantigen #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virulence #Virus entry into host cell
- ORF7a protein · Gene: 7a · Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) · 121 amino acids · Evidence at protein level · Annotation score: 5/5#G0/G1 host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host adaptive immune response by virus #Inhibition of host innate immune response by virus #Inhibition of host MHC class I molecule presentation by virus #Inhibition of host tetherin by virus #Modulation of host cell cycle by virus #Viral immunoevasion
- Envelope glycoprotein gp160 · Gene: env · Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2) · 851 amino acids · Inferred from homology · Annotation score: 5/5#Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host tetherin by virus #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Virus endocytosis by host #Virus entry into host cell #AIDS
- Protein Vpu · Gene: vpu · Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1) · 81 amino acids · Evidence at protein level · Annotation score: 5/5