Keywords - G1/S host cell cycle checkpoint dysregulation by virus (KW-1078)
- DefinitionViral protein involved in the modulation of host cell cycle progression by dysregulating the G1/S transition. Some viruses benefit from an arrest in G1 to S phase transition, while others force through S phase to favor their own replication.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalG1/S host cell cycle checkpoint dysregulation by virus
Related UniProtKB entries
Browse all 7,371 entries- Large T antigen · WU polyomavirus (WUPyV) · EC:5.6.2.4 · 648 amino acids · Evidence at protein level · Annotation score: 5/5#DNA-binding #Helicase #Hydrolase #Isomerase #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 6d (isolate VN235) (HCV) · 3013 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Large T antigen · Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) · EC:5.6.2.4 · 751 amino acids · Inferred from homology · Annotation score: 5/5#DNA-binding #Helicase #Hydrolase #Isomerase #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion #Oncogene
- DNA polymerase processivity factor BMRF1 · Gene: BMRF1 · Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) · 404 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Hepatitis C virus genotype 1b (isolate BK) (HCV) · 3010 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 1a (isolate 1) (HCV) · 3011 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- mRNA export factor · Gene: UL54 · Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) · 512 amino acids · Evidence at protein level · Annotation score: 5/5#Activator #RNA-binding #Activation of host NF-kappa-B by virus #Eukaryotic host gene expression shutoff by virus #G1/S host cell cycle checkpoint dysregulation by virus #Host gene expression shutoff by virus #Host mRNA suppression by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host IRF3 by virus #Inhibition of host pre-mRNA processing by virus #Inhibition of host RLR pathway by virus #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Viral immunoevasion
- Genome polyprotein · Hepatitis C virus genotype 1b (isolate Taiwan) (HCV) · 3010 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 1b (isolate HC-JT) (HCV) · 3010 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 6a (isolate 6a33) (HCV) · 3019 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 6g (isolate JK046) (HCV) · 3022 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Oncoprotein MEQ · Gene: MDV005 (MDV076) · Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) · 339 amino acids · Evidence at protein level · Annotation score: 5/5
- Replication-associated protein A · Gene: C1 · Bean yellow dwarf virus (BeYDV) · EC:3.1.21.- · 292 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Hepatitis C virus genotype 6a (isolate EUHK2) (HCV) · 3018 amino acids · Inferred from homology · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 4a (isolate ED43) (HCV) · 3008 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 1b (strain HC-J4) (HCV) · 3010 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Protein Rep68 · Gene: Rep68 · Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) · EC:3.6.4.12 · 536 amino acids · Evidence at protein level · Annotation score: 5/5#DNA-binding #Endonuclease #Hydrolase #Nuclease #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host G2/M cell cycle arrest by virus #Host-virus interaction #Modulation of host cell cycle by virus #Viral penetration into host cytoplasm #Viral penetration via permeabilization of host membrane #Virus entry into host cell
- Protein Tax-1 · Gene: Tax · Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) · 353 amino acids · Evidence at protein level · Annotation score: 5/5#Activator #DNA-binding #Activation of host NF-kappa-B by virus #G0/G1 host cell cycle checkpoint dysregulation by virus #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host mitotic exit by virus #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Oncogene
- Large T antigen · KI polyomavirus (isolate Stockholm 380) (KIPyV) · EC:5.6.2.4 · 641 amino acids · Inferred from homology · Annotation score: 5/5#DNA-binding #Helicase #Hydrolase #Isomerase #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion #Oncogene
- Large T antigen · Murine polyomavirus (strain BG) (MPyV) · EC:5.6.2.4 · 782 amino acids · Evidence at protein level · Annotation score: 5/5#DNA-binding #Helicase #Hydrolase #Isomerase #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion #Oncogene
- Large T antigen · Mus musculus polyomavirus 1 (MPyV) · EC:5.6.2.4 · 782 amino acids · Inferred from homology · Annotation score: 5/5#DNA-binding #Helicase #Hydrolase #Isomerase #DNA replication #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host JAK1 by virus #Interferon antiviral system evasion #Modulation of host cell cycle by virus #Viral immunoevasion #Oncogene
- Viral transcription factor IE2 · Gene: UL122 · Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) · 580 amino acids · Evidence at protein level · Annotation score: 5/5
- Genome polyprotein · Hepatitis C virus genotype 2a (isolate HC-J6) (HCV) · 3033 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 2b (isolate HC-J8) (HCV) · 3033 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene
- Genome polyprotein · Hepatitis C virus genotype 3a (isolate NZL1) (HCV) · 3021 amino acids · Evidence at protein level · Annotation score: 5/5#Helicase #Hydrolase #Ion channel #Multifunctional enzyme #Nucleotidyltransferase #Protease #Ribonucleoprotein #RNA-binding #RNA-directed RNA polymerase #Serine protease #Thiol protease #Transferase #Viral ion channel #Viral nucleoprotein #Activation of host autophagy by virus #Apoptosis #Clathrin-mediated endocytosis of virus by host #Fusion of virus membrane with host endosomal membrane #Fusion of virus membrane with host membrane #G1/S host cell cycle checkpoint dysregulation by virus #Host-virus interaction #Inhibition of host innate immune response by virus #Inhibition of host interferon signaling pathway by virus #Inhibition of host MAVS by virus #Inhibition of host RLR pathway by virus #Inhibition of host STAT1 by virus #Inhibition of host TRAFs by virus #Interferon antiviral system evasion #Ion transport #Modulation of host cell cycle by virus #Transcription #Transcription regulation #Transport #Viral attachment to host cell #Viral immunoevasion #Viral penetration into host cytoplasm #Viral RNA replication #Virus endocytosis by host #Virus entry into host cell #Oncogene