Keywords - Tricarboxylic acid cycle (KW-0816)
- DefinitionProtein involved in the tricarboxylic acid cycle, a series of metabolic reactions in aerobic cellular respiration, which occurs in the mitochondria of animals and plants and in which acetyl-CoA, formed from pyruvate produced during glycolysis, is completely oxidized to CO2 via the interconversion of various carboxylic acids. It results in the reduction of NAD and FAD to NADH and FADH2, whose reducing power is then used indirectly in the synthesis of ATP by oxidative phosphorylation. The TCA cycle also provides intermediates for many other biosynthetic processes.
- Synonyms
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalTricarboxylic acid cycle
Related UniProtKB entries
Browse all 402,420 entries- Citrate synthase, mitochondrial · Gene: CS · Homo sapiens (Human) · EC:2.3.3.1 · 466 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial · Gene: SDHA (SDH2, SDHF) · Homo sapiens (Human) · EC:1.3.5.1 · 664 amino acids · Evidence at protein level · Annotation score: 5/5
- Malate dehydrogenase, cytoplasmic · Gene: MDH1 (MDHA) · Homo sapiens (Human) · EC:1.1.1.37 · 334 amino acids · Evidence at protein level · Annotation score: 5/5
- Isocitrate dehydrogenase [NADP], mitochondrial · Gene: IDH2 · Homo sapiens (Human) · EC:1.1.1.42 · 452 amino acids · Evidence at protein level · Annotation score: 5/5
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial · Gene: IDH3A · Homo sapiens (Human) · EC:1.1.1.41 · 366 amino acids · Evidence at protein level · Annotation score: 5/5
- Cytoplasmic aconitate hydratase · Gene: ACO1 (IREB1) · Homo sapiens (Human) · EC:4.2.1.3 · 889 amino acids · Evidence at protein level · Annotation score: 5/5
- Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial · Gene: IDH3G · Homo sapiens (Human) · 393 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial · Gene: SUCLG2 · Homo sapiens (Human) · EC:6.2.1.4 · 432 amino acids · Evidence at protein level · Annotation score: 5/5
- Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial · Gene: IDH3B · Homo sapiens (Human) · 385 amino acids · Evidence at protein level · Annotation score: 5/5
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial · Gene: PDHA2 (PDHAL) · Homo sapiens (Human) · EC:1.2.4.1 · 388 amino acids · Evidence at protein level · Annotation score: 5/5
- Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial · Gene: DLST (DLTS) · Homo sapiens (Human) · EC:2.3.1.61 · 453 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial · Gene: SUCLG1 · Homo sapiens (Human) · EC:6.2.1.4, EC:6.2.1.5 · 346 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial · Gene: SDHC (CYB560, SDH3) · Homo sapiens (Human) · 169 amino acids · Evidence at protein level · Annotation score: 5/5
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial · Gene: PDHA1 (PHE1A) · Homo sapiens (Human) · EC:1.2.4.1 · 390 amino acids · Evidence at protein level · Annotation score: 5/5
- Malate dehydrogenase, mitochondrial · Gene: MDH2 · Homo sapiens (Human) · EC:1.1.1.37 · 338 amino acids · Evidence at protein level · Annotation score: 5/5
- Aconitate hydratase, mitochondrial · Gene: ACO2 · Homo sapiens (Human) · EC:4.2.1.3 · 780 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial · Gene: SDHD (SDH4) · Homo sapiens (Human) · 159 amino acids · Evidence at protein level · Annotation score: 5/5
- Isocitrate dehydrogenase [NADP] cytoplasmic · Gene: IDH1 (PICD) · Homo sapiens (Human) · EC:1.1.1.42 · 414 amino acids · Evidence at protein level · Annotation score: 5/5
- Fumarate hydratase, mitochondrial · Gene: FH · Homo sapiens (Human) · EC:4.2.1.2 · 510 amino acids · Evidence at protein level · Annotation score: 5/5
- Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial · Gene: DLAT (DLTA) · Homo sapiens (Human) · EC:2.3.1.12 · 647 amino acids · Evidence at protein level · Annotation score: 5/5
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial · Gene: PDHB (PHE1B) · Homo sapiens (Human) · EC:1.2.4.1 · 359 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial · Gene: SDHB (SDH, SDH1) · Homo sapiens (Human) · EC:1.3.5.1 · 280 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial · Gene: SUCLA2 · Homo sapiens (Human) · EC:6.2.1.5 · 463 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial · Gene: SDH1-1 · Arabidopsis thaliana (Mouse-ear cress) · EC:1.3.5.1 · 634 amino acids · Evidence at protein level · Annotation score: 5/5
- Succinate dehydrogenase iron-sulfur subunit · Gene: sdhB · Escherichia coli (strain K12) · EC:1.3.5.1 · 238 amino acids · Evidence at protein level · Annotation score: 5/5