Keywords - Topoisomerase (KW-0799)
- DefinitionEnzymes capable of altering the degree of supercoiling of double- stranded DNA molecules. Various topoisomerases can increase or relax supercoiling, convert single-stranded rings to intertwined double- stranded rings, tie and untie knots in single stranded and duplex rings or catenate and decatenate duplex rings. Any enzyme that cleaves only one strand of a DNA duplex and then reseals it is classified as a type I topoisomerase (Topo I). Type II topoisomerases (Topo II) change DNA topology by breaking and rejoining double-stranded DNA.
- Category
- Gene Ontology (GO)
- Ancestors
- Graphical
Related UniProtKB entries
Browse all 296,078 entries- Meiotic recombination protein SPO11 · Gene: SPO11 · Homo sapiens (Human) · EC:5.6.2.2 · 396 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 2-alpha · Gene: TOP2A (TOP2) · Homo sapiens (Human) · EC:5.6.2.2 · 1531 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 2-beta · Gene: TOP2B · Homo sapiens (Human) · EC:5.6.2.2 · 1626 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 3-alpha · Gene: TOP3A (TOP3) · Homo sapiens (Human) · EC:5.6.2.1 · 1001 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase I, mitochondrial · Gene: TOP1MT · Homo sapiens (Human) · EC:5.6.2.1 · 601 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 3-beta-1 · Gene: TOP3B (TOP3B1) · Homo sapiens (Human) · EC:5.6.2.1 · 862 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 1 · Gene: TOP1 · Homo sapiens (Human) · EC:5.6.2.1 · 765 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA gyrase subunit A · Gene: gyrA (hisW, nalA, parD) · Escherichia coli (strain K12) · EC:5.6.2.2 · 875 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 3 · Gene: TOP3 (EDR1) · Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) · EC:5.6.2.1 · 656 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 2-alpha · Gene: Top2a (Top-2, Top2) · Mus musculus (Mouse) · EC:5.6.2.2 · 1528 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 2 top-2 · Gene: top-2 · Caenorhabditis elegans · EC:5.6.2.2 · 1520 amino acids · Evidence at protein level · Annotation score: 5/5
- Meiotic recombination protein SPO11 · Gene: Spo11 · Mus musculus (Mouse) · EC:5.6.2.2 · 396 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 3 · Gene: topB · Escherichia coli (strain K12) · EC:5.6.2.1 · 653 amino acids · Evidence at protein level · Annotation score: 5/5
- Meiosis-specific protein SPO11 · Gene: SPO11 · Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) · EC:5.6.2.2 · 398 amino acids · Evidence at protein level · Annotation score: 5/5
- Meiotic recombination protein W68 · Gene: mei-W68 · Drosophila melanogaster (Fruit fly) · EC:5.6.2.2 · 331 amino acids · Evidence at transcript level · Annotation score: 5/5
- DNA topoisomerase 3-alpha · Gene: Top3alpha · Drosophila melanogaster (Fruit fly) · EC:5.6.2.1 · 1250 amino acids · Evidence at transcript level · Annotation score: 5/5
- DNA topoisomerase 1 alpha · Gene: TOP1A (FAS5, MGO1, TOP1, TOP1ALPHA) · Arabidopsis thaliana (Mouse-ear cress) · EC:5.6.2.1 · 916 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 2-alpha · Gene: Top2a (Top-2, Top2) · Rattus norvegicus (Rat) · EC:5.6.2.2 · 1526 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 1 · Gene: Top1 (Top-1) · Mus musculus (Mouse) · EC:5.6.2.1 · 767 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA gyrase subunit A, chloroplastic/mitochondrial · Gene: GYRA · Arabidopsis thaliana (Mouse-ear cress) · EC:5.6.2.2 · 950 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 3-alpha · Gene: TOP3A · Arabidopsis thaliana (Mouse-ear cress) · EC:5.6.2.1 · 926 amino acids · Evidence at protein level · Annotation score: 5/5
- Meiotic recombination protein SPO11-2 · Gene: SPO11-2 · Arabidopsis thaliana (Mouse-ear cress) · EC:5.6.2.2 · 383 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 1 · Gene: top-1 · Caenorhabditis elegans · EC:5.6.2.1 · 806 amino acids · Evidence at transcript level · Annotation score: 5/5
- DNA topoisomerase 2 · Gene: Top2 · Drosophila melanogaster (Fruit fly) · EC:5.6.2.2 · 1447 amino acids · Evidence at protein level · Annotation score: 5/5
- DNA topoisomerase 1 · Gene: Top1 · Drosophila melanogaster (Fruit fly) · EC:5.6.2.1 · 972 amino acids · Evidence at protein level · Annotation score: 5/5