Keywords - Long QT syndrome (KW-0454)
- DefinitionProtein which, if defective, causes the long QT syndrome, a heart disease which manifests itself by a prolonged QT interval on the ECG and, clinically, by a propensity for tachyarrhythmias, causing syncopes and sudden cardiac death. LQTS may be drug-induced, but mutations in genes coding for cardiac ion-channels are the cause of the hereditary forms: Romano-Ward syndrome (RWS), and Jervell and Lange-Nielsen Syndrome (JLNS).
- Synonyms
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalLong QT syndrome
Related UniProtKB entries
Browse all 16 entries- G protein-activated inward rectifier potassium channel 4 · Gene: KCNJ5 (GIRK4) · Homo sapiens (Human) · 419 amino acids · Evidence at protein level · Annotation score: 5/5
- Caveolin-3 · Gene: CAV3 · Homo sapiens (Human) · 151 amino acids · Evidence at protein level · Annotation score: 5/5
- Calmodulin-3 · Gene: CALM3 (CALML2, CAM3, CAMC, CAMIII) · Homo sapiens (Human) · 149 amino acids · Evidence at protein level · Annotation score: 5/5
- Inward rectifier potassium channel 2 · Gene: KCNJ2 (IRK1) · Homo sapiens (Human) · 427 amino acids · Evidence at protein level · Annotation score: 5/5
- Sodium channel protein type 5 subunit alpha · Gene: SCN5A · Homo sapiens (Human) · 2016 amino acids · Evidence at protein level · Annotation score: 5/5
- Sodium channel subunit beta-4 · Gene: SCN4B · Homo sapiens (Human) · 228 amino acids · Evidence at protein level · Annotation score: 5/5
- Potassium voltage-gated channel subfamily E member 2 · Gene: KCNE2 · Homo sapiens (Human) · 123 amino acids · Evidence at protein level · Annotation score: 5/5
- Calmodulin-2 · Gene: CALM2 (CAM2, CAMB) · Homo sapiens (Human) · 149 amino acids · Evidence at protein level · Annotation score: 5/5
- Potassium voltage-gated channel subfamily E member 1 · Gene: KCNE1 · Homo sapiens (Human) · 129 amino acids · Evidence at protein level · Annotation score: 5/5
- A-kinase anchor protein 9 · Gene: AKAP9 (AKAP350, AKAP450, KIAA0803) · Homo sapiens (Human) · 3907 amino acids · Evidence at protein level · Annotation score: 5/5
- Calmodulin-1 · Gene: CALM1 (CALM, CAM, CAM1) · Homo sapiens (Human) · 149 amino acids · Evidence at protein level · Annotation score: 5/5
- Potassium voltage-gated channel subfamily KQT member 1 · Gene: KCNQ1 (KCNA8, KCNA9, KVLQT1) · Homo sapiens (Human) · 676 amino acids · Evidence at protein level · Annotation score: 5/5
- Ankyrin-2 · Gene: ANK2 (ANKB) · Homo sapiens (Human) · 3957 amino acids · Evidence at protein level · Annotation score: 5/5
- Voltage-gated inwardly rectifying potassium channel KCNH2 · Gene: KCNH2 (ERG, ERG1, HERG) · Homo sapiens (Human) · 1159 amino acids · Evidence at protein level · Annotation score: 5/5
- Alpha-1-syntrophin · Gene: SNTA1 (SNT1) · Homo sapiens (Human) · 505 amino acids · Evidence at protein level · Annotation score: 5/5
- Voltage-dependent L-type calcium channel subunit alpha-1C · Gene: CACNA1C (CACH2, CACN2, CACNL1A1, CCHL1A1) · Homo sapiens (Human) · 2221 amino acids · Evidence at protein level · Annotation score: 5/5