Keywords - Integrin (KW-0401)
- DefinitionProtein of the integrin family of cell surface heterodimeric receptors that mediates dynamic cell-to-cell as well as cell-to-matrix adhesion. Integrins function as mechanochemical sensors and transducers able to change rapidly and reversibly their adhesive functions by modulating their ligand-binding affinity. Each subunit has a large N-terminal extracellular domain followed by a transmembrane domain and a short C- terminal cytoplasmic region. Some subclasses of integrins share a common beta chain while having different alpha chains.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalIntegrin
Related UniProtKB entries
Browse all 49,639 entries- Integrin beta-3 · Gene: ITGB3 (GP3A) · Homo sapiens (Human) · 788 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-V · Gene: ITGAV (MSK8, VNRA, VTNR) · Homo sapiens (Human) · 1048 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-5 · Gene: ITGA5 (FNRA) · Homo sapiens (Human) · 1049 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-5 · Gene: ITGB5 · Homo sapiens (Human) · 799 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-4 · Gene: ITGA4 (CD49D) · Homo sapiens (Human) · 1032 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-11 · Gene: ITGA11 · Homo sapiens (Human) · 1188 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-6 · Gene: ITGB6 · Homo sapiens (Human) · 788 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-L · Gene: ITGAL (CD11A) · Homo sapiens (Human) · 1170 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-X · Gene: ITGAX (CD11C) · Homo sapiens (Human) · 1163 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-3 · Gene: ITGA3 (MSK18) · Homo sapiens (Human) · 1051 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-8 · Gene: ITGB8 · Homo sapiens (Human) · 769 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-7 · Gene: ITGA7 · Homo sapiens (Human) · 1181 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-1 · Gene: ITGB1 (FNRB, MDF2, MSK12) · Homo sapiens (Human) · 798 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-M · Gene: ITGAM (CD11B, CR3A) · Homo sapiens (Human) · 1152 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-2 · Gene: ITGA2 (CD49B) · Homo sapiens (Human) · 1181 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-6 · Gene: ITGA6 · Homo sapiens (Human) · 1130 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-1 · Gene: ITGA1 · Homo sapiens (Human) · 1179 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-10 · Gene: ITGA10 · Homo sapiens (Human) · 1167 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-2 · Gene: ITGB2 (CD18, MFI7) · Homo sapiens (Human) · 769 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-IIb · Gene: ITGA2B (GP2B, ITGAB) · Homo sapiens (Human) · 1039 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-4 · Gene: ITGB4 · Homo sapiens (Human) · 1822 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin beta-7 · Gene: ITGB7 · Homo sapiens (Human) · 798 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-E · Gene: ITGAE · Homo sapiens (Human) · 1179 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-8 · Gene: ITGA8 · Homo sapiens (Human) · 1063 amino acids · Evidence at protein level · Annotation score: 5/5
- Integrin alpha-D · Gene: ITGAD · Homo sapiens (Human) · 1161 amino acids · Evidence at protein level · Annotation score: 5/5