Keywords - Autophagy (KW-0072)
- DefinitionProtein participating in autophagy, a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. There are three primary forms of autophagy: chaperone-mediated autophagy, microautophagy and macroautophagy. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment.
- Category
- Gene Ontology (GO)
- Ancestors
- GraphicalAutophagy
Related UniProtKB entries
Browse all 115,207 entries- Galectin-8 · Gene: LGALS8 · Homo sapiens (Human) · 317 amino acids · Evidence at protein level · Annotation score: 5/5
- Ubiquitin-like modifier-activating enzyme ATG7 · Gene: ATG7 (APG7L) · Homo sapiens (Human) · 703 amino acids · Evidence at protein level · Annotation score: 5/5
- Tyrosine-protein kinase ABL1 · Gene: ABL1 (ABL, JTK7) · Homo sapiens (Human) · EC:2.7.10.2 · 1130 amino acids · Evidence at protein level · Annotation score: 5/5
- Lysosome-associated membrane glycoprotein 2 · Gene: LAMP2 · Homo sapiens (Human) · 410 amino acids · Evidence at protein level · Annotation score: 5/5
- X-box-binding protein 1 · Gene: XBP1 (TREB5, XBP2) · Homo sapiens (Human) · 261 amino acids · Evidence at protein level · Annotation score: 5/5
- Transcription factor EB · Gene: TFEB (BHLHE35) · Homo sapiens (Human) · 476 amino acids · Evidence at protein level · Annotation score: 5/5
- Arfaptin-2 · Gene: ARFIP2 (POR1) · Homo sapiens (Human) · 341 amino acids · Evidence at protein level · Annotation score: 5/5
- Transitional endoplasmic reticulum ATPase · Gene: VCP (HEL-220, HEL-S-70) · Homo sapiens (Human) · EC:3.6.4.6 · 806 amino acids · Evidence at protein level · Annotation score: 5/5
- Syntaxin-17 · Gene: STX17 · Homo sapiens (Human) · 302 amino acids · Evidence at protein level · Annotation score: 5/5
- Protein CLEC16A · Gene: CLEC16A (KIAA0350) · Homo sapiens (Human) · 1053 amino acids · Evidence at protein level · Annotation score: 5/5
- Armadillo repeat-containing protein 3 · Gene: ARMC3 · Homo sapiens (Human) · 872 amino acids · Evidence at protein level · Annotation score: 5/5
- Ras-related protein Rab-12 · Gene: RAB12 · Homo sapiens (Human) · 244 amino acids · Evidence at protein level · Annotation score: 5/5
- E3 ubiquitin-protein ligase LRSAM1 · Gene: LRSAM1 (TAL) · Homo sapiens (Human) · EC:2.3.2.27 · 723 amino acids · Evidence at protein level · Annotation score: 5/5
- RUN and FYVE domain-containing protein 4 · Gene: RUFY4 · Homo sapiens (Human) · 571 amino acids · Evidence at protein level · Annotation score: 5/5
- Tax1-binding protein 1 · Gene: TAX1BP1 (T6BP) · Homo sapiens (Human) · 789 amino acids · Evidence at protein level · Annotation score: 5/5
- Myotubularin-related protein 13 · Gene: SBF2 (CMT4B2, KIAA1766, MTMR13) · Homo sapiens (Human) · 1849 amino acids · Evidence at protein level · Annotation score: 5/5
- FUN14 domain-containing protein 1 · Gene: FUNDC1 · Homo sapiens (Human) · 155 amino acids · Evidence at protein level · Annotation score: 5/5
- Tumor protein p53-inducible nuclear protein 2 · Gene: TP53INP2 (C20orf110, DOR, PINH) · Homo sapiens (Human) · 220 amino acids · Evidence at protein level · Annotation score: 5/5
- WD repeat and FYVE domain-containing protein 3 · Gene: WDFY3 (KIAA0993) · Homo sapiens (Human) · 3526 amino acids · Evidence at protein level · Annotation score: 5/5
- Reticulophagy regulator 2 · Gene: RETREG2 (C2orf17, FAM134A, MAG2) · Homo sapiens (Human) · 543 amino acids · Evidence at protein level · Annotation score: 5/5
- Transcription factor SPT20 homolog · Gene: SUPT20H (C13orf19, FAM48A) · Homo sapiens (Human) · 779 amino acids · Evidence at protein level · Annotation score: 5/5
- Ubiquitin carboxyl-terminal hydrolase 13 · Gene: USP13 (ISOT3) · Homo sapiens (Human) · EC:3.4.19.12 · 863 amino acids · Evidence at protein level · Annotation score: 5/5
- Optineurin · Gene: OPTN (FIP2, GLC1E, HIP7, HYPL, NRP) · Homo sapiens (Human) · 577 amino acids · Evidence at protein level · Annotation score: 5/5
- Ras-related protein Rab-39B · Gene: RAB39B · Homo sapiens (Human) · 213 amino acids · Evidence at protein level · Annotation score: 5/5
- Activating molecule in BECN1-regulated autophagy protein 1 · Gene: AMBRA1 (DCAF3, KIAA1736) · Homo sapiens (Human) · 1298 amino acids · Evidence at protein level · Annotation score: 5/5