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Literature citations Results

Unraveling cholesterol catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha2beta2 acyl-CoA dehydrogenase initiates beta-oxidation of 3-oxo-cholest-4-en-26-oyl CoA.

Yang M., Lu R., Guja K.E., Wipperman M.F., St Clair J.R., Bonds A.C., Garcia-Diaz M., Sampson N.S.

ACS Infect. Dis. 1:110-125(2015) · UniProtKB (5)

Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase.

Kursula I., Salin M., Sun J., Norledge B.V., Haapalainen A.M., Sampson N.S., Wierenga R.K.

Protein Eng. Des. Sel. 17:375-382(2004) · Mapped (1)

The presence of a hydrogen bond between asparagine 485 and the pi system of FAD modulates the redox potential in the reaction catalyzed by cholesterol oxidase.

Yin Y., Sampson N.S., Vrielink A., Lario P.I.

Biochemistry 40:13779-13787(2001) · Mapped (1)

The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase.

Chen L., Lyubimov A.Y., Brammer L., Vrielink A., Sampson N.S.

Biochemistry 47:5368-5377(2008) · Mapped (1)

Segmental motion in catalysis: investigation of a hydrogen bond critical for loop closure in the reaction of triosephosphate isomerase.

Sampson N.S., Knowles J.R.

Biochemistry 31:8488-8494(1992) · Mapped (1)

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

Yang X., Dubnau E., Smith I., Sampson N.S.

Biochemistry 46:9058-9067(2007) · UniProtKB (1)

Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides.

Dufour A., Zucker S., Sampson N.S., Kuscu C., Cao J.

J. Biol. Chem. 285:35944-35956(2010) · Mapped (7)

Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.

Thomas S.T., VanderVen B.C., Sherman D.R., Russell D.G., Sampson N.S.

J. Biol. Chem. 286:43668-43678(2011) · UniProtKB (2)

Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain.

Thomas S.T., Sampson N.S.

Biochemistry 52:2895-2904(2013) · UniProtKB (2)

Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration.

Zarrabi K., Dufour A., Li J., Kuscu C., Pulkoski-Gross A., Zhi J., Hu Y., Sampson N.S., Zucker S., Cao J.

J. Biol. Chem. 286:33167-33177(2011) · Mapped (5)

Global gene expression analysis reveals a role for the alpha 1 integrin in renal pathogenesis.

Sampson N.S., Ryan S.T., Enke D.A., Cosgrove D., Koteliansky V., Gotwals P.

J. Biol. Chem. 276:34182-34188(2001) · Mapped (8)

FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis.

Schaefer C.M., Lu R., Nesbitt N.M., Schiebel J., Sampson N.S., Kisker C.

Structure 23:21-33(2015) · UniProtKB (1)

Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase.

Lyubimov A.Y., Heard K., Tang H., Sampson N.S., Vrielink A.

Protein Sci. 16:2647-2656(2007) · Mapped (1)

Diacyltransferase activity and chain length specificity of Mycobacterium tuberculosis PapA5 in the synthesis of alkyl beta-diol lipids.

Touchette M.H., Bommineni G.R., Delle Bovi R.J., Gadbery J.E., Nicora C.D., Shukla A.K., Kyle J.E., Metz T.O., Martin D.W., Sampson N.S. et al.

Biochemistry 54:5457-5468(2015) · UniProtKB (1)

Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.

Bone R., Sampson N.S., Bartlett P.A., Agard D.A.

Biochemistry 30:2263-2272(1991) · Mapped (1)

Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants.

Yue Q.K., Kass I.J., Sampson N.S., Vrielink A.

Biochemistry 38:4277-4286(1999) · UniProtKB (1)

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

Lu R., Schaefer C.M., Nesbitt N.M., Kuper J., Kisker C., Sampson N.S.

ACS Infect Dis 3:666-675(2017) · Mapped (1)

Beta1 integrin is an adhesion protein for sperm binding to eggs.

Baessler K.A., Lee Y., Sampson N.S.

ACS Chem. Biol. 4:357-366(2009) · Mapped (2)

Alpha-methyl acyl CoA racemase provides Mycobacterium tuberculosis catabolic access to cholesterol esters.

Lu R., Schmitz W., Sampson N.S.

Biochemistry 54:5669-5672(2015) · UniProtKB (2)

A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.

Nesbitt N.M., Yang X., Fontan P., Kolesnikova I., Smith I., Sampson N.S., Dubnau E.

Infect. Immun. 78:275-282(2010) · UniProtKB (1)

A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase.

Lyubimov A.Y., Chen L., Sampson N.S., Vrielink A.

Acta Crystallogr. D Biol. Crystallogr. 65:1222-1231(2009) · Mapped (1)

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