Literature citations

Evolutionary clustering and functional similarity of RNA-binding proteins.

RNA-binding proteins (RNPs) involved in splicing, processing and translation regulation contain one to four RNA-binding domains. We constructed a phylogenetic tree for the RNA-binding domains, including those of poly(A)- binding protein (PABP), splicing factors, chloroplast RNPs, hnRNPs, snRNP U1- 70K, nucleolin and Drosophila sex determinants. Proteins with similar functions were found to have closely related RNA-binding domains and common domain organizations. In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA- binding domain(s) and domain organization, as compared with other RNPs.

Related UniProtKB entries

Browse all 22 entries
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp