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W1QDS0 · W1QDS0_OGAPD

Function

function

Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site194sulfate (UniProtKB | ChEBI)
Binding site194-197ATP (UniProtKB | ChEBI)
Active site195
Active site196
Binding site196sulfate (UniProtKB | ChEBI)
Active site197
Site200Transition state stabilizer
Site203Transition state stabilizer
Binding site288-291ATP (UniProtKB | ChEBI)
Binding site292sulfate (UniProtKB | ChEBI)
Site327Induces change in substrate recognition on ATP binding
Binding site330ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processcysteine biosynthetic process
Biological Processhydrogen sulfide biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processsulfate assimilation via adenylyl sulfate reduction
Biological Processsulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfate adenylyltransferase
  • EC number
  • Alternative names
    • ATP-sulfurylase
    • Sulfate adenylate transferase
      (SAT
      )

Gene names

    • Name
      MET3
    • ORF names
      HPODL_03492

Organism names

Accessions

  • Primary accession
    W1QDS0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer. Dimer of trimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-166N-terminal
Domain4-161ATP-sulfurylase PUA-like
Domain170-384Sulphate adenylyltransferase catalytic
Region392-547Required for oligomerization; adenylyl-sulfate kinase-like

Domain

The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

Sequence similarities

Belongs to the sulfate adenylyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    60,807
  • Last updated
    2014-03-19 v1
  • MD5 Checksum
    79A56FC9997D1360046B0A3847D3EDE6
MLVPHGGVLQDLLQRDAPIKSELIAEAATLKSLSLTDRQLCDLELILVGGFSPLTGFLNEADYTSVVHKMRLSTGEVWPIPITLDVSKQVSSQFKSGDRVVLRDPRDDLALAILTVGDIYTPDKQLEAKEVFRGDPEHPAIRYLFDVAGEVYIGGALQAINAPKHYDYTELRKTPAQLRTEFANKHWSKVVAFQTRNPMHRAHRELTVRAARDKLANLLIHPVVGLTKPGDIDHHTRVKVYQEIIKKYPNGMAQLALLPLAMRMAGDREALWHSIIRKNYGATHFIVGRDHAGPGSNSKGVPFYGPYDAQELVERFSTELEIEVVPFRMVTYLPDEARYAPIDSIPDGTKTLNISGTELRKRLREGTHIPEWFSYPEVVKILRTAYPPRQTQGFALYLQGLPNSGVEALSYALQATFNQFAGGRHITLLDAAKIGRGAVSFVLGELVRSGAGVIVVNNEEVVSNTELSAIRKAVAKSGTFVVVSVETPRAVCEANDRRGYFQASRKDIEGYEVPADAEIRVDLDSLPINTAIQKIVLYLEEEGFFVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AEOI02000007
EMBL· GenBank· DDBJ
ESW99613.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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