W0DBY5 · W0DBY5_9AQUI
- ProteinDelta-aminolevulinic acid dehydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids327 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 120 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 122 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Binding site | 130 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: C | ||||||
Active site | 195 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 205 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 217 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 233 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 248 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 274 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 313 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | porphobilinogen synthase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Aquificota > Aquificia > Aquificales > Aquificaceae > Thermocrinis
Accessions
- Primary accessionW0DBY5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Sequence
- Sequence statusComplete
- Length327
- Mass (Da)36,544
- Last updated2014-03-19 v1
- Checksum458B5EA0163EBA96
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP007028 EMBL· GenBank· DDBJ | AHE95746.1 EMBL· GenBank· DDBJ | Genomic DNA |