V9IED1 · V9IED1_APICE

Function

function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Catalytic activity

  • (2E)-decenoyl-[ACP] + NADPH + H+ = decanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-dodecenoyl-[ACP] + NADPH + H+ = dodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexadecenoyl-[ACP] + NADPH + H+ = hexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexenoyl-[ACP] + NADPH + H+ = hexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-octadecenoyl-[ACP] + NADPH + H+ = octadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-octenoyl-[ACP] + NADPH + H+ = octanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-tetradecenoyl-[ACP] + NADPH + H+ = tetradecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • 3-oxobutanoyl-[ACP] + NADPH + H+ = (3R)-hydroxybutanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxodecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxydecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxododecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxydodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexadecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyhexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyhexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctadecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyoctadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctanoyl-[ACP] + NADPH + H+ = (3R)-hydroxyoctanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxotetradecanoyl-[ACP] + NADPH + H+ = (3R)-hydroxytetradecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • a (3R)-hydroxyacyl-[ACP] + NADP+ = a 3-oxoacyl-[ACP] + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.100 (UniProtKB | ENZYME | Rhea)
  • a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.59 (UniProtKB | ENZYME | Rhea)
  • a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.39 (UniProtKB | ENZYME | Rhea)
  • a fatty acyl-[ACP] + malonyl-[ACP] + H+ = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
    EC:2.3.1.41 (UniProtKB | ENZYME | Rhea)
  • acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
    EC:2.3.1.85 (UniProtKB | ENZYME | Rhea)
  • acetyl-[ACP] + malonyl-[ACP] + H+ = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • butanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • decanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • dodecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H+
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • hexadecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • hexanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.38 (UniProtKB | ENZYME | Rhea)
  • octanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.
  • tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H+
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • tetradecanoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site883Proton acceptor; for dehydratase activity
Active site1036Proton donor; for dehydratase activity

GO annotations

AspectTerm
Molecular Function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Function3-oxoacyl-[acyl-carrier-protein] synthase activity
Molecular Function[acyl-carrier-protein] S-acetyltransferase activity
Molecular Functionenoyl-[acyl-carrier-protein] reductase (NADPH) activity
Molecular Functionfatty acid synthase activity
Molecular Functionfatty acyl-[ACP] hydrolase activity
Molecular Functionphosphopantetheine binding
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • ORF names
      ACCB01260.2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Apis

Accessions

  • Primary accession
    V9IED1

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain11-416Ketosynthase family 3 (KS3)
Region847-972N-terminal hotdog fold
Domain847-1115PKS/mFAS DH
Region987-1115C-terminal hotdog fold
Domain2006-2091Carrier

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,371
  • Mass (Da)
    262,656
  • Last updated
    2014-03-19 v1
  • MD5 Checksum
    9BFCD69A443F3209FDBFC8C74207A1C9
MNGDTTPYNINDEIVISGFSGRYPESSNVEEFKKNLFEGIDMVTNDDRRWPSGMYGLPERSGKLKELNLFDATFFGVHAKQAHVMDPQLRILLEATYEAIVDAGINPNDIKGSKTGVFIGVSASESDEYWTKDPDQINGYALTGCCRAMFPNRISYSFDFNGPSYAIDTACSSSLYAMHQAIASIRSGECNSAIVGGCNLLLKPTQSLQFNRLSMLSSDGMCKAFDADGKGYVRSEAVSVLFLQKAKDARRVYATVIHSKTNTDGNKVQGITFPNGEMQNKLMREIYAEAGINPADVSYVEAHGTGTKVGDPQEVNSIANLFCKGRKTPLLLGSVKSNMGHSEPASGVCSISKLLIAMEEGIIPGNLHFKIPNADIPALNDGSIQVVDKNMPWKGGLVAVNSFGFGGANAHILFRSHPKPKLLPVLDSKVPKLVTICGRTEEAVRVLLNKAQEYEKDDEFIALLHDIYANNISNHLYRGYSIMGNVKLEEINQYVDKKHPIWFVFSGMGSQWPGMGKDLLNIEIFQRSLRKCAEALKPEGIDLMNLILNGTSETFENVLHSFVSIAAIQVALVDVLTYLEIQPDGIVGHSVGELGCAYADGTFTPEQTVLAAYWRGKTIMDSNLQLGAMAAVGLSWEEVAARCPPDVTPACNNASDSVTISGPIESLKKFIEELKKDNIFVKMVNSSGVAFHSKYVAPVGQKLRTMLEKIIPNPKQRSSRWISTSIPEQAWSTPLAQLSSAAYHVNNLLSPVLFYQALSHIPEDAIVIEIAPHSLLQAILRRSLPSSVTNIGLHKRNHSNNLNLLLENIGKIYMAGGQPKISKLYPPVNYPVGHGTPMINSLVKWDHSMQWDVATFSSASSSFGENIVEFDLAKESDEYLVGHNIDERILFPATGYLLITWKTFAKLRGVDYEQLPITFENVKFQRATIMPKEGVVKFLINIFMGTGQFEICENGSVAVTGTISVPDDINKMLLNIPAPILKKESESLELNTNDIYKELRLRGYHYSGIFQGIKSISNRGVSGRLLWNNNWIAFIDTMLQFSILGKDTRGLYVPVRLQYAAINPIVHLDFIKNYKENEGAPVYFYSNIDVIKSGGIEIRKMKASLITKKQQHRIPKLEKYLFIPFENSQPLAQDPEKAKQYALTVLLQIVCENIGRKKTKIVEVAGNRPIDYLFVPDIIQFSNLEIQLNFEVQVVVDSRKQYSGLEELNVTIVIRNEEKEPVAENSHLIIASNILSNNSWNILKNLTDSLLNNGFLFLEETSQIDVNSANLLNQNMIHIATQVVAGSSYHLFRKKEHRSAPIVIQITEKNFMWLEGVKAALKKVATENQELLLVSQGEELLGMIGFMNCIRQEDGGAKASYVFIQDKNLPKFNLNDKFYTHQLSKHLVANVLKGGQWGSYRHLQLDLQNEESLQVEHANINVLYRGDLSSLRWIESSLSYYQPEKFPNTLLCSVYYAPLNFRDIMLATGKLPPDALPGNLATQECILGLEFSGRDPKGQRIMSMVAARGLATTVVADPNFMWKVPDKWSLEQAATIPVAYATSYYALCVRGRMKRGDSVLIHAGSGGVGQASISIALHTGCTVFTTVGTQEKRDFLKKMFPQLTDKNIGNSRDTSFEQLILTETNGRGVDIVLNSLAEEKLQASVRCLAIGGRFLEIGKFDLSNDSPLGMSVFLKNASFHGILLDAILEGDSPDRRETARLINEGIESGAVRPLPSTVFSEQQIEQSFRFMATGKHIGKVLLKIRDEEKEKIIQPSTKIVSAIPRTYMNPEKSYIIIGGLGGFGLELSEWMIIRGAKYIVLTSRSGIRTGFQSLCIRRWREMGVHVKISTIDIVTLTGAKQLIKESNEFAPIGGIFNLAAVLRDGLIENLSESDFVISASPKITVTKNLDIVSREYCSSLDYFVVFSSVSCGRGNIGQSNYGLSNSAMERIMENRQANGLPGLAIQWGAIGDVGLIIDAMKGSSDTEIGGTLPQRIQSCLDTIDIFLQQPHPVLSSMIIADKRVEIGTKISVVEAVANIMGIKALESINPSVTLADLGMDSLMGTEIKQTLERNYDLILSALEIRTLTFGKLQQLDTPTAEEQVNTTDSEEDIVEDFLFQVNSSELVPIKSLVQLETKSSKGQPIFIVHAIEGTQTPFKTLASELERPVWSFQCIENSPLESVSALAAFYVKEMQKIQAKEPYHVAGYSFGACIAFEMAVQLEKAGKAVVLTLLDGSPAYVKLHSVEIGKLANQDDVSANGYRKSLSYFIRQFNKKINFIQAYDILKSVSDEELLDKVVEIIDEPQLDVKDLKVAGLLFYKKLLAVYNYNPSVFNGDILLIRAKDNFVDLDEDYGLSKICKKKIKIEKLPGNHRSILAGKNASQIANILRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JR039355
EMBL· GenBank· DDBJ
AEY58654.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help