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V9HFS6 · V9HFS6_9CLOT

  • Protein
    Aspartate-semialdehyde dehydrogenase
  • Gene
    asd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-13NADP+ (UniProtKB | ChEBI)
Binding site38-39NADP+ (UniProtKB | ChEBI)
Binding site100phosphate (UniProtKB | ChEBI)
Active site129Acyl-thioester intermediate
Binding site156substrate
Binding site159-160NADP+ (UniProtKB | ChEBI)
Binding site229substrate
Active site236Proton acceptor
Binding site309NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      CSBG_01229

Organism names

  • Taxonomic identifier
  • Strain
    • 7_2_43FAA
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    V9HFS6

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-120Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    330
  • Mass (Da)
    36,613
  • Last updated
    2014-02-19 v1
  • MD5 Checksum
    BD299FDA778ABC45522A131746759526
MYNVAIVGATGNVGRKFLEILEERNFPIKTLYLFASKRSAGSKLKFKENEILVEETLEKNIKNKKIDFALFSAGGDISLKFSPIFASYGAIVIDNSSAFRMDKNVPLVVPEVNPEDITWHNGIIANPNCSTIQAMIPLKVLLENYGIKRIVYSTYQAVSGAGMQGIADLEDGIKGLAPKKFPYPIAGNCLPHIDVFLDNGYTKEEIKMIEETKKILHNSNLKITATAVRVPVLNSHSESINVELEKPYELNDIINLFINAKGLTVYDNINELEYPTALMASGKDDVFVGRIRRDFSTDNGLNLWVVADNIRKGAALNAVQIAELLIRSDM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACDK02000032
EMBL· GenBank· DDBJ
EEH97603.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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