U6Q3E0 · U6Q3E0_9CLOT

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site18Nucleophile
Binding site254[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site301Mg2+ (UniProtKB | ChEBI)
Binding site363Mg2+ (UniProtKB | ChEBI)
Binding site364Mg2+ (UniProtKB | ChEBI)
Binding site400[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site450[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site453[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      CSBG_03474

Organism names

  • Taxonomic identifier
  • Strain
    • 7_2_43FAA
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    U6Q3E0

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-238Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    51,016
  • Last updated
    2014-01-22 v1
  • Checksum
    FA4AB9E6BADDDCAD
MNSNLILDPDNDKFKDECGVFGVYVNKPMDVASMTYYGLYALQHRGQESAGIAVANGEGVDIHKGMGLITEAFSKEDLNRLKGFAAIGHVRYSTCGDTRIENAQPLLSQTKLGSIAMAHNGTLVNADVIRELLEDGGHVFHTSIDSEVIANLIARGAKKGIEKAIYDSIQAIRGSFAMVILTKDKLIGVRDPHGIRPLCLGKTEEGYVLSSESCALDAIGAELIRDVEPGEIIIIDDNGIKSYKYSENTQCQTCAFEYIYFARPDSTIDGLDVHESRVRAGEQLFREYKIDADVVVAVPDSGIPSAIGYSKASGIPYDTGFVKNRYVGRTFITPSQEIRERAVAVKLNPLKSNISGKKVVLIDDSIVRGTTSKHLVDSLRRAGAKEVHFLVASPIVKFPCYFGIDTPYRSELIGAKKSIEEIREAIGCDSLGYLSMEGMYSCFKENCGYCVGCFNGIYPVATPIEGAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACDK02000013
EMBL· GenBank· DDBJ
EJZ50489.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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