U3BC34 · U3BC34_CALJA
- ProteinPlatelet-derived growth factor receptor beta
- GenePDGFRB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1108 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 579 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 606-614 | ATP (UniProtKB | ChEBI) | |||
Binding site | 607-614 | ATP (UniProtKB | ChEBI) | |||
Binding site | 634 | ATP (UniProtKB | ChEBI) | |||
Binding site | 682-688 | ATP (UniProtKB | ChEBI) | |||
Active site | 826 | Proton acceptor | |||
Binding site | 830 | ATP (UniProtKB | ChEBI) | |||
Binding site | 831 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 844 | Mg2+ (UniProtKB | ChEBI) | |||
Site | 970 | Important for interaction with phosphotyrosine-binding proteins | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlatelet-derived growth factor receptor beta
- EC number
- Short namesPDGF-R-beta ; PDGFR-beta
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionU3BC34
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 532-556 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-32 | ||||
Chain | PRO_5004638634 | 33-1108 | Platelet-derived growth factor receptor beta | ||
Keywords
- PTM
Interaction
Subunit
Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-111 | Ig-like | |||
Domain | 214-307 | Ig-like | |||
Domain | 600-962 | Protein kinase | |||
Region | 1017-1108 | Disordered | |||
Compositional bias | 1043-1060 | Polar residues | |||
Compositional bias | 1066-1090 | Acidic residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,108
- Mass (Da)124,207
- Last updated2013-11-13 v1
- MD5 Checksum462036B98B484C10A91CBD46CC8E6789
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1043-1060 | Polar residues | |||
Compositional bias | 1066-1090 | Acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMT01008677 EMBL· GenBank· DDBJ | JAB03184.1 EMBL· GenBank· DDBJ | mRNA |