U3BC34 · U3BC34_CALJA

Function

function

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.

Catalytic activity

Features

Showing features for binding site, active site, site.

111081002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site579Mg2+ (UniProtKB | ChEBI)
Binding site606-614ATP (UniProtKB | ChEBI)
Binding site607-614ATP (UniProtKB | ChEBI)
Binding site634ATP (UniProtKB | ChEBI)
Binding site682-688ATP (UniProtKB | ChEBI)
Active site826Proton acceptor
Binding site830ATP (UniProtKB | ChEBI)
Binding site831Mg2+ (UniProtKB | ChEBI)
Binding site844Mg2+ (UniProtKB | ChEBI)
Site970Important for interaction with phosphotyrosine-binding proteins

GO annotations

AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentlysosomal lumen
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionboss receptor activity
Molecular Functionbrain-derived neurotrophic factor receptor activity
Molecular Functionepidermal growth factor receptor activity
Molecular Functionfibroblast growth factor receptor activity
Molecular FunctionGPI-linked ephrin receptor activity
Molecular Functionhepatocyte growth factor receptor activity
Molecular Functionhistone H2AXY142 kinase activity
Molecular Functionhistone H3Y41 kinase activity
Molecular Functioninsulin receptor activity
Molecular Functioninsulin-like growth factor receptor activity
Molecular Functionmacrophage colony-stimulating factor receptor activity
Molecular Functionmetal ion binding
Molecular Functionplacental growth factor receptor activity
Molecular Functionplatelet-derived growth factor alpha-receptor activity
Molecular Functionplatelet-derived growth factor beta-receptor activity
Molecular Functionplatelet-derived growth factor binding
Molecular Functionprotein tyrosine kinase collagen receptor activity
Molecular Functionstem cell factor receptor activity
Molecular Functiontransmembrane-ephrin receptor activity
Molecular Functionvascular endothelial growth factor receptor activity
Biological Processangiogenesis
Biological Processcell chemotaxis
Biological Processpositive regulation of smooth muscle cell migration
Biological Processregulation of cell population proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-derived growth factor receptor beta
  • EC number
  • Short names
    PDGF-R-beta
    ; PDGFR-beta
  • Alternative names
    • Beta platelet-derived growth factor receptor
    • Beta-type platelet-derived growth factor receptor

Gene names

    • Name
      PDGFRB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix

Accessions

  • Primary accession
    U3BC34

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cytoplasmic vesicle
Lysosome lumen
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane532-556Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_500463863433-1108Platelet-derived growth factor receptor beta

Keywords

Interaction

Subunit

Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain20-111Ig-like
Domain214-307Ig-like
Domain600-962Protein kinase
Region1017-1108Disordered
Compositional bias1043-1060Polar residues
Compositional bias1066-1090Acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,108
  • Mass (Da)
    124,207
  • Last updated
    2013-11-13 v1
  • MD5 Checksum
    462036B98B484C10A91CBD46CC8E6789
MQLPGVMPALALKGQLLLLPLLLLLEPQVSQGLVITPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGSFFSVLTLSNLTGLDTGEYFCTYNDSHGLELDERKRLYIFVPDPTVVFLPNDAEELFIFLTEITETTIPCRVTDPQLVVTLHEKKGDVALPVLYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTSPRQESGRLVEPVTDFLLDMPYHIRSILHIPSAELDDSGTYICNVTESVNDHQDEKAINVTVVESGYVRLLGELGALQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPDIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTVRLQHVDRPMSVRCTLRNAVGQDMQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGIPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYTAPYDNYVPSAPERTCQATLINESPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPVHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNESDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQEEPEPEPQLELQVEPDPEPELEQPPDSGCPAPRPEAEDSFL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1043-1060Polar residues
Compositional bias1066-1090Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GAMT01008677
EMBL· GenBank· DDBJ
JAB03184.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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