S8C072 · S8C072_9LAMI
- ProteinDNA-(apurinic or apyrimidinic site) endonuclease 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids608 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 37 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 153 | |||||
Sequence: Y | ||||||
Active site | 194 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 194 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 196 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 196 | Transition state stabilizer | ||||
Sequence: N | ||||||
Site | 265 | Important for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 322 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 323 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 323 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 323 | Interaction with DNA substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | phosphoric diester hydrolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | base-excision repair |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDNA-(apurinic or apyrimidinic site) endonuclease 2
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Lentibulariaceae > Genlisea
Accessions
- Primary accessionS8C072
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 514-535 | Disordered | ||||
Sequence: ENNIPVQEDGGNPPQSAGKQKN | ||||||
Domain | 556-605 | GRF-type | ||||
Sequence: CKGHQEPCVPRVVKKPGVNFGRRFYTCARAEGPASNPEANCGFFKWAAAK |
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length608
- Mass (Da)68,187
- Last updated2013-10-16 v1
- Checksum0296E2DA71D15F98
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 608 | |||||
Sequence: K |
Keywords
- Technical term