Q9ZSK1 · GTOMC_ARATH
- ProteinTocopherol O-methyltransferase, chloroplastic
- GeneVTE4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids348 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the synthesis of tocopherol (vitamin E). Methylates gamma- and delta-tocopherol to form beta- and alpha-tocopherol, respectively.
Miscellaneous
Seeds overexpressing VTE4 show increased levels of alpha-tocopherol.
Catalytic activity
- gamma-tocopherol + S-adenosyl-L-methionine = +-alpha-tocopherol + S-adenosyl-L-homocysteine + H+
Pathway
Cofactor biosynthesis; tocopherol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | nucleus | |
Molecular Function | S-adenosylmethionine-dependent methyltransferase activity | |
Molecular Function | tocopherol C-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | vitamin E biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameTocopherol O-methyltransferase, chloroplastic
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9ZSK1
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Slight reduction of fresh weight in mature plants. Leaves with high levels of gamma-tocopherol and absence of alpha-tocopherol.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-51 | Chloroplast | |||
Modified residue | 52 | N-acetylalanine | |||
Chain | PRO_0000018677 | 52-348 | Tocopherol O-methyltransferase, chloroplastic | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 130-139 | SAM motif I | |||
Region | 193-201 | SAM motif II | |||
Region | 220-229 | SAM motif III | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length348
- Mass (Da)38,075
- Last updated2005-05-10 v2
- MD5 Checksum4B81648DFAB82D82CCC96F6AE0B49E05
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 175 | in Ref. 1; AAD02882 and 5; AAM64696 | |||
Sequence conflict | 188 | in Ref. 5; AAM64696 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF104220 EMBL· GenBank· DDBJ | AAD02882.1 EMBL· GenBank· DDBJ | mRNA | ||
AC006193 EMBL· GenBank· DDBJ | AAD38271.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE34310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY049258 EMBL· GenBank· DDBJ | AAK83600.1 EMBL· GenBank· DDBJ | mRNA | ||
AY090280 EMBL· GenBank· DDBJ | AAL90941.1 EMBL· GenBank· DDBJ | mRNA | ||
AY087138 EMBL· GenBank· DDBJ | AAM64696.1 EMBL· GenBank· DDBJ | mRNA |