Q9NC65 · ADA_LUTLO
- ProteinAdenosine deaminase
- GeneADA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids508 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the deamination of adenosine to inosine.
Catalytic activity
- adenosine + H2O + H+ = inosine + NH4+
Cofactor
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
8.4 μM | adenosine |
pH Dependence
Optimum pH is 5-8.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | 2'-deoxyadenosine deaminase activity | |
Molecular Function | adenosine deaminase activity | |
Molecular Function | metal ion binding | |
Biological Process | adenosine catabolic process | |
Biological Process | inosine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine deaminase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Psychodoidea > Psychodidae > Lutzomyia > Lutzomyia
Accessions
- Primary accessionQ9NC65
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5004335413 | 19-508 | Adenosine deaminase | ||
Expression
Tissue specificity
Salivary gland (at protein level).
Structure
Family & Domains
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length508
- Mass (Da)58,393
- Last updated2000-10-01 v1
- Checksum93AC01CEBF4F8B76
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF234182 EMBL· GenBank· DDBJ | AAF78901.1 EMBL· GenBank· DDBJ | mRNA |