Q9GTP7 · APY_PHLPP
- ProteinApyrase
- GeneAPY
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids336 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host (By similarity).
Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate in calcium-dependent manner (PubMed:11136609).
Triggers proliferation of host peripheral blood mononuclear cells (PBMCs) and IFN-gamma/IFNG production (PubMed:29054598).
Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate in calcium-dependent manner (PubMed:11136609).
Triggers proliferation of host peripheral blood mononuclear cells (PBMCs) and IFN-gamma/IFNG production (PubMed:29054598).
Catalytic activity
- a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | apyrase activity | |
Molecular Function | ATP binding | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent ATPase activity | |
Molecular Function | GDP phosphatase activity | |
Molecular Function | nucleoside diphosphate phosphatase activity | |
Molecular Function | toxin activity | |
Molecular Function | UDP phosphatase activity | |
Biological Process | immune system process | |
Biological Process | proteoglycan biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameApyrase
- EC number
- Short namesPPTSP36 ; PpApy
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Psychodoidea > Psychodidae > Phlebotomus > Phlebotomus
Accessions
- Primary accessionQ9GTP7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5004326568 | 22-336 | Apyrase | ||
Glycosylation | 209 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Expression
Tissue specificity
Salivary gland (at protein level).
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length336
- Mass (Da)38,158
- Last updated2001-03-01 v1
- Checksum8A77B90A821B1829
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 6-7 | in Ref. 2; AGE83101 | |||
Sequence conflict | 61 | in Ref. 2; AGE83101 | |||
Sequence conflict | 110 | in Ref. 2; AGE83101 | |||
Sequence conflict | 226 | in Ref. 2; AGE83101 | |||
Sequence conflict | 236 | in Ref. 2; AGE83101 | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF261768 EMBL· GenBank· DDBJ | AAG17637.1 EMBL· GenBank· DDBJ | mRNA | ||
JQ988892 EMBL· GenBank· DDBJ | AGE83101.1 EMBL· GenBank· DDBJ | mRNA |