Q9GTP7 · APY_PHLPP

Function

function

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host (By similarity).
Cleaves adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP) and inorganic phosphate in calcium-dependent manner (PubMed:11136609).
Triggers proliferation of host peripheral blood mononuclear cells (PBMCs) and IFN-gamma/IFNG production (PubMed:29054598).

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionapyrase activity
Molecular FunctionATP binding
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent ATPase activity
Molecular FunctionGDP phosphatase activity
Molecular Functionnucleoside diphosphate phosphatase activity
Molecular Functiontoxin activity
Molecular FunctionUDP phosphatase activity
Biological Processimmune system process
Biological Processproteoglycan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Apyrase
  • EC number
  • Short names
    PPTSP36
    ; PpApy
  • Alternative names
    • Salivary apyrase

Gene names

    • Name
      APY

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Psychodoidea > Psychodidae > Phlebotomus > Phlebotomus

Accessions

  • Primary accession
    Q9GTP7
  • Secondary accessions
    • M1JB52

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500432656822-336Apyrase
Glycosylation209N-linked (GlcNAc...) asparagine

Keywords

Expression

Tissue specificity

Salivary gland (at protein level).

Structure

Family & Domains

Sequence similarities

Belongs to the apyrase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    336
  • Mass (Da)
    38,158
  • Last updated
    2001-03-01 v1
  • Checksum
    8A77B90A821B1829
MFLKFCIVAFAICLSINLSEGAPRSGTIYNFAIIADLDKKSISPKNDNNYKSIVKVGELIEVGDKYSVKMKKEDHEIFTKYAYKGRGAELSEFLIYKWKLYTFDDKSGIVFRLKTNADLIPWVTLANGNGDQTDGFKAEWATTKGDKMYVGSTGISFTDKTGKLNSNSLWIKEIDQDGKVQSLDWKEQYDKIKSAMKIPNGFIWHEAVNWSKLKNQWVFLPRKCSERPFDTKTEETIGCNKIIIASENFEIIKSIQIKGKSINRAAGFSSFKFLPDSDDQILLALKTIEKDDKTATYITVIDITGRVLMPEMQINSDKYEGIVLLKSTEGFLKRSQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict6-7in Ref. 2; AGE83101
Sequence conflict61in Ref. 2; AGE83101
Sequence conflict110in Ref. 2; AGE83101
Sequence conflict226in Ref. 2; AGE83101
Sequence conflict236in Ref. 2; AGE83101

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF261768
EMBL· GenBank· DDBJ
AAG17637.1
EMBL· GenBank· DDBJ
mRNA
JQ988892
EMBL· GenBank· DDBJ
AGE83101.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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