Q90341 · MYC1_CYPCA

Function

function

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionprotein dimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processpositive regulation of cell population proliferation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator Myc-1
  • Short names
    c-Myc-1
  • Alternative names
    • c-Myc I

Gene names

    • Name
      myca
    • Synonyms
      cam1, myc1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Cyprininae > Cyprinus

Accessions

  • Primary accession
    Q90341

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00001273161-394Transcriptional regulator Myc-1
Glycosylation58O-linked (GlcNAc) threonine

Keywords

PTM databases

Interaction

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).

Structure

Family & Domains

Features

Showing features for motif, region, compositional bias, domain.

Type
IDPosition(s)Description
Motif76-849aaTAD
Region177-247Disordered
Compositional bias204-226Acidic residues
Region283-318Disordered
Compositional bias298-318Basic and acidic residues
Domain310-362bHLH
Region369-390Leucine-zipper

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    44,996
  • Last updated
    1996-11-01 v1
  • Checksum
    7146C81C920D71D0
MPVSASLAYKNYDYDYDSIQPYFYFDNDDEDFYHHQQGQTQPPAPSEDIWKKFELLPTPPLSPSRRQSLSTAEQLEMVSEFLGDDVVNQSFICDADYSQSFIKSIIIQDCMWSGFSAAAKLEKVVSERLASLHAARKELMSDSSSNRLNASYLQDVSTSASECIDPSVVFPYPLPESGKSSKVAPSEPMPVLDTPPNSSSSSGSDSEEEEEEEEEEEEEEEEEEIDVVTVEKRQKKNETAVSDSRYPSPLVLKRCHVSTHQHNYAAHPSTRHDQPAVKRLRLEASSNSNSRHVKQRKCTSPRTSDSEDNDKRRTHNVLERQRRNELKLSFFALRDEIPDVANNEKAAKVVILKKATECIHSMQLDEQRLLSIKEQLRRKSEQLKHRLQLLRSSH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias204-226Acidic residues
Compositional bias298-318Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D37887
EMBL· GenBank· DDBJ
BAA07129.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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