Q6E7H0 · ORC3_ARATH
- ProteinOrigin of replication complex subunit 3
- GeneORC3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids734 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear origin of replication recognition complex | |
Cellular Component | origin recognition complex | |
Molecular Function | DNA binding | |
Biological Process | DNA replication | |
Biological Process | lateral root development | |
Biological Process | response to sucrose |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameOrigin of replication complex subunit 3
- Short namesAtORC3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ6E7H0
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000431431 | 1-734 | Origin of replication complex subunit 3 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Follow a cell-cycle regulation with a peak at the G1/S-phase (PubMed:16179646).
Mostly expressed in siliques and flowers, and, to a lower exent, in flower buds, leaves, roots and stems (PubMed:15358564, PubMed:16179646).
Mostly expressed in siliques and flowers, and, to a lower exent, in flower buds, leaves, roots and stems (PubMed:15358564, PubMed:16179646).
Induction
Regulated by E2F (PubMed:16126853, PubMed:16179646).
Accumulates rapidly after cell cycle reactivation by sucrose addition following cell cycle arrest mediated by sucrose deprivation (PubMed:15358564, PubMed:16179646).
Accumulates rapidly after cell cycle reactivation by sucrose addition following cell cycle arrest mediated by sucrose deprivation (PubMed:15358564, PubMed:16179646).
Gene expression databases
Interaction
Subunit
Component of the origin recognition complex (ORC) composed of at least ORC1 (ORC1A or ORC1B), ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts directly with ORC1A, ORC2, ORC4, ORC5 and ORC6.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-25 | Disordered | |||
Compositional bias | 8-25 | Polar residues | |||
Region | 532-554 | Disordered | |||
Sequence similarities
Belongs to the ORC3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length734
- Mass (Da)82,755
- Last updated2004-08-16 v1
- MD5 ChecksumF4869ED2732EC1ED625AEDB56CAD7E4E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8BC82 | A0A1P8BC82_ARATH | ORC3 | 710 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 8-25 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY524002 EMBL· GenBank· DDBJ | AAT37463.1 EMBL· GenBank· DDBJ | mRNA | ||
AL391147 EMBL· GenBank· DDBJ | CAC01833.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED92326.1 EMBL· GenBank· DDBJ | Genomic DNA |