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Q5WG43 · Q5WG43_SHOC1

Function

function

Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

S-adenosyl-L-methionine (UniProtKB | Rhea| CHEBI:59789 )

Note: Binds 1 S-adenosyl-L-methionine per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10substrate
Binding site14[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site18[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site20-22S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site21[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site23Mg2+ (UniProtKB | ChEBI)
Binding site59substrate
Binding site61S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site105-107S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionmagnesium ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological Processqueuosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-carboxy-7-deazaguanine synthase
  • EC number
  • Short names
    CDG synthase
  • Alternative names
    • Queuosine biosynthesis protein QueE

Gene names

    • Name
      queE
    • Ordered locus names
      ABC2127

Organism names

Accessions

  • Primary accession
    Q5WG43

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-213Radical SAM core

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    217
  • Mass (Da)
    24,504
  • Last updated
    2004-11-23 v1
  • MD5 Checksum
    A6A3B55AF286122F9B50F70281E780C0
MIGQKTMFVRTGGCDYRCRWCDSAFTWDGSEKSEPLSAEEIIERLDSLCENGYSHVTISGGNPAIHKGIGELVALLNEKGVATAIETQGSIFQCWINRVDEVTVSPKPPSSGMETDWTKLDLFLQQLQAPAVSLKVVVFDDADYQYAKHVHKRYPTVPFYLQTGNEDFAEKEDPRFLEKRMGAYEALVEKALADKEMNNVRVLPQLHTWLWGNKRGV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP006627
EMBL· GenBank· DDBJ
BAD64662.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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