Q4XST6 · ASNA_PLACU

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Features

Showing features for binding site, active site.

138050100150200250300350
Type
IDPosition(s)Description
Binding site48-55ATP (UniProtKB | ChEBI)
Active site77
Binding site248ATP (UniProtKB | ChEBI)
Binding site275ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processtail-anchored membrane protein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog
    • Arsenite-stimulated ATPase

Gene names

    • ORF names
      PC000665.03.0, PCHAS_0726100

Organism names

  • Taxonomic identifier
  • Strains
    • AS
    • AJ
    • CB
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)

Accessions

  • Primary accession
    Q4XST6
  • Secondary accessions
    • A0A077TJS0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003881701-380ATPase ASNA1 homolog

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the arsA ATPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,852
  • Last updated
    2005-07-05 v1
  • MD5 Checksum
    B1F323F2089C85465C6D4A8E739DA2C0
MSKAGSDASSISCSLSLDSDSCDDEFYETNLNKLIENTSLNWIFVGGKGGVGKTTTSCSIAIQLAKKRESVLLLSTDPAHNTSDAFNQKFTNKPTLINSFDNLYCMEIDTTFSEDTAFKINKSDFLNSIIPELLQSFPGIDEALCFAELMQSIRNMKYSVIVFDTAPTGHTLRLLAFPDLLKKALGYLINLKEKLKGTLNMLQSLTSNEMEFEGMYDKINHLNTMSISIQENFQNPLKTTFVCVCIPEFLSVYETERLIQELTKKNISCYNIVVNQVVFPLTSQDANIESCEGLLKQIKDTNIKDSFSSLILKAKELEDVYISRRKLQSKYLTQIKNLYGNYFHIVCMPQLKSEIRGLDKIASFSEMLLQSKDIPIYSPQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LK022884
EMBL· GenBank· DDBJ
VTZ68131.1
EMBL· GenBank· DDBJ
Genomic DNA
LT608173
EMBL· GenBank· DDBJ
SCM01131.1
EMBL· GenBank· DDBJ
Genomic DNA
LT608159
EMBL· GenBank· DDBJ
SCM02720.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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