Q4XST6 · ASNA_PLACU
- ProteinATPase ASNA1 homolog
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 48-55 | ATP (UniProtKB | ChEBI) | |||
Active site | 77 | ||||
Binding site | 248 | ATP (UniProtKB | ChEBI) | |||
Binding site | 275 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | GET complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | tail-anchored membrane protein insertion into ER membrane |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATPase ASNA1 homolog
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Vinckeia)
Accessions
- Primary accessionQ4XST6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000388170 | 1-380 | ATPase ASNA1 homolog | ||
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,852
- Last updated2005-07-05 v1
- MD5 ChecksumB1F323F2089C85465C6D4A8E739DA2C0
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LK022884 EMBL· GenBank· DDBJ | VTZ68131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT608173 EMBL· GenBank· DDBJ | SCM01131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LT608159 EMBL· GenBank· DDBJ | SCM02720.1 EMBL· GenBank· DDBJ | Genomic DNA |