Q11QE1 · ENO_CYTH3
- ProteinEnolase
- Geneeno
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids427 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.
Catalytic activity
- (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
Cofactor
Note: Binds a second Mg2+ ion via substrate during catalysis.
Pathway
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 163 | (2R)-2-phosphoglycerate (UniProtKB | ChEBI) | |||
Active site | 205 | Proton donor | |||
Binding site | 242 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 288 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 315 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 340 | Proton acceptor | |||
Binding site | 340 | (2R)-2-phosphoglycerate (UniProtKB | ChEBI) | |||
Binding site | 369 | (2R)-2-phosphoglycerate (UniProtKB | ChEBI) | |||
Binding site | 370 | (2R)-2-phosphoglycerate (UniProtKB | ChEBI) | |||
Binding site | 391 | (2R)-2-phosphoglycerate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular region | |
Cellular Component | phosphopyruvate hydratase complex | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphopyruvate hydratase activity | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnolase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Cytophagia > Cytophagales > Cytophagaceae > Cytophaga
Accessions
- Primary accessionQ11QE1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Fractions of enolase are present in both the cytoplasm and on the cell surface.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000267023 | 1-427 | Enolase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)46,046
- Last updated2006-08-22 v1
- MD5 Checksum01B308A33783903704C53CF575F5BFE9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000383 EMBL· GenBank· DDBJ | ABG60373.1 EMBL· GenBank· DDBJ | Genomic DNA |