Q06K46 · SP15B_PHLDU
- ProteinSalivary protein 15b
- GeneK03
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids142 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Inhibits contact coagulation pathway activation in the host by sequestering anionic polymers, such as dextran sulfate and heparin, and thus blocking interaction of protein components of the pathway with negatively charged surfaces (PubMed:24092749).
Inhibits dextran sulfate-mediated autoactivation of host coagulation factor XII (F12) (PubMed:24092749).
Inhibits dextran sulfate-mediated activation of host factor XI (F11) by activated F12 (PubMed:24092749).
Inhibits polyphosphate-induced plasma extravasation at the injection site in mouse model, probably via inhibition of bradykinin generation in host skin (PubMed:24092749).
Inhibits dextran sulfate-mediated autoactivation of host coagulation factor XII (F12) (PubMed:24092749).
Inhibits dextran sulfate-mediated activation of host factor XI (F11) by activated F12 (PubMed:24092749).
Inhibits polyphosphate-induced plasma extravasation at the injection site in mouse model, probably via inhibition of bradykinin generation in host skin (PubMed:24092749).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | odorant binding |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSalivary protein 15b
- Short namesPdSP15b
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Psychodoidea > Psychodidae > Phlebotomus > Phlebotomus
Accessions
- Primary accessionQ06K46
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_0000461519 | 21-142 | Salivary protein 15b | ||
Disulfide bond | 27↔44 | ||||
Disulfide bond | 40↔108 | ||||
Disulfide bond | 91↔117 | ||||
Keywords
- PTM
Expression
Tissue specificity
Female salivary gland.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length142
- Mass (Da)16,599
- Last updated2006-10-31 v1
- Checksum13C4DD53141BF78B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ826524 EMBL· GenBank· DDBJ | ABI15943.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ835372 EMBL· GenBank· DDBJ | ABI20177.1 EMBL· GenBank· DDBJ | mRNA |