P74755 · HIS2_SYNY3
- ProteinHistidine biosynthesis bifunctional protein HisIE
- GenehisI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids215 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H+
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | phosphoribosyl-AMP cyclohydrolase activity | |
Molecular Function | phosphoribosyl-ATP diphosphatase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidine biosynthesis bifunctional protein HisIE
Including 2 domains:
- Recommended namePhosphoribosyl-AMP cyclohydrolase
- EC number
- Short namesPRA-CH
- Recommended namePhosphoribosyl-ATP pyrophosphatase
- EC number
- Short namesPRA-PH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Merismopediaceae > Synechocystis
Accessions
- Primary accessionP74755
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000136440 | 1-215 | Histidine biosynthesis bifunctional protein HisIE | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-126 | Phosphoribosyl-AMP cyclohydrolase | |||
Region | 127-215 | Phosphoribosyl-ATP pyrophosphohydrolase | |||
Sequence similarities
In the N-terminal section; belongs to the PRA-CH family.
In the C-terminal section; belongs to the PRA-PH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length215
- Mass (Da)23,945
- Last updated2002-06-06 v2
- ChecksumD8720E7D4BB80B60
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000022 EMBL· GenBank· DDBJ | BAA18875.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |