P74755 · HIS2_SYNY3

Function

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionphosphoribosyl-ATP diphosphatase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidine biosynthesis bifunctional protein HisIE

Including 2 domains:

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH
  • Recommended name
    Phosphoribosyl-ATP pyrophosphatase
  • EC number
  • Short names
    PRA-PH

Gene names

    • Name
      hisI
    • Synonyms
      hisIE
    • Ordered locus names
      slr0608

Organism names

Accessions

  • Primary accession
    P74755

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001364401-215Histidine biosynthesis bifunctional protein HisIE

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-126Phosphoribosyl-AMP cyclohydrolase
Region127-215Phosphoribosyl-ATP pyrophosphohydrolase

Sequence similarities

In the N-terminal section; belongs to the PRA-CH family.
In the C-terminal section; belongs to the PRA-PH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,945
  • Last updated
    2002-06-06 v2
  • Checksum
    D8720E7D4BB80B60
MSHSDLPLANAVPLDKIRYNDQGLVPAIAQDYLDGTVLMLAWMNEAALAKTLATGQVWYWSRSRQELWHKGATSGHFQKLLGIRYDCDSDALLLTIEQKGDIACHTGERSCFHQLDGHKSPPPADMLTELARVIGDRRDHPTPESYTCKLLAGGDNKILKKIGEESAEVVMACKDDDPEAIAGEVADLFYHTLVALAHHNVDLRAVYRKLGDRRR

Sequence caution

The sequence BAA18875.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000022
EMBL· GenBank· DDBJ
BAA18875.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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