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P53358 · PCNA_STYCL

  • Protein
    Proliferating cell nuclear antigen
  • Gene
    PCNA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

Features

Showing features for dna binding.

126420406080100120140160180200220240260
TypeIDPosition(s)Description
DNA binding61-80

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentPCNA complex
Molecular FunctionDNA binding
Molecular FunctionDNA polymerase processivity factor activity
Biological Processleading strand elongation
Biological Processmismatch repair
Biological Processregulation of DNA replication
Biological Processtranslesion synthesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Proliferating cell nuclear antigen
  • Short names
    PCNA
  • Alternative names
    • Cyclin

Gene names

    • Name
      PCNA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Tunicata > Ascidiacea > Stolidobranchia > Styelidae > Styela

Accessions

  • Primary accession
    P53358

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001491721-264Proliferating cell nuclear antigen

Interaction

Subunit

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the PCNA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    29,260
  • Last updated
    1996-10-01 v1
  • MD5 Checksum
    4106236CE0F628E64666955744D1B50D
MFEARLIQGSNLKKVQEALKDIVTEASWDCTSSGISLQAMDSSHVSLVQLTLRADGFENFRCDRNLAMGINMTSMAKIMKCAGNDDIITLRAEDNADMLELIFESSKGDKYSQYEMKLMDLDCEQLGIPEQDYSCCVTLPSQEFGRICRDLSQIGECVVITCTKDGVQFSAKGDLGAGKIKLKQNTGSDIKEEEQVTVEISEPVQLTFAIKYLNLFAKASPLSPSVCLSMSNNVPLVVEYKVADMGHIKYFLAPKIEDEEEQDS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L42763
EMBL· GenBank· DDBJ
AAC37303.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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