P45860 · CLS1_BACSU
- ProteinProbable cardiolipin synthase YwiE
- GeneywiE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids500 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity).
May have a role in the heat shock response since the level of the transcript of ywiE increases after a heat shock
May have a role in the heat shock response since the level of the transcript of ywiE increases after a heat shock
Catalytic activity
- 2 a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 242 | ||||
Active site | 244 | ||||
Active site | 249 | ||||
Active site | 418 | ||||
Active site | 420 | ||||
Active site | 425 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cardiolipin synthase activity | |
Biological Process | cardiolipin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable cardiolipin synthase YwiE
- EC number
- Short namesCL synthase 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionP45860
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-26 | Helical | |||
Transmembrane | 31-51 | Helical | |||
Transmembrane | 59-79 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000201247 | 1-500 | Probable cardiolipin synthase YwiE | ||
Proteomic databases
Expression
Induction
By heat shock.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 237-264 | PLD phosphodiesterase 1 | |||
Domain | 413-440 | PLD phosphodiesterase 2 | |||
Sequence similarities
Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length500
- Mass (Da)58,248
- Last updated1995-11-01 v1
- Checksum3BEF85FD4F0681B8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z49884 EMBL· GenBank· DDBJ | CAA90049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z49782 EMBL· GenBank· DDBJ | CAA89861.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL009126 EMBL· GenBank· DDBJ | CAB15752.1 EMBL· GenBank· DDBJ | Genomic DNA |