P45100 · RLMM_HAEIN
- ProteinRibosomal RNA large subunit methyltransferase M
- GenerlmM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
Catalytic activity
- cytidine2498 in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine2498 in 23S rRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 194 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 227-230 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 246 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 266 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 284 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 313 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | S-adenosylmethionine-dependent methyltransferase activity | |
Biological Process | methylation | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA large subunit methyltransferase M
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionP45100
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000070406 | 1-363 | Ribosomal RNA large subunit methyltransferase M | ||
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length363
- Mass (Da)41,563
- Last updated1995-11-01 v1
- ChecksumDC7B76D1B192D524
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L42023 EMBL· GenBank· DDBJ | AAC22849.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |