P11972 · SST2_YEAST
- ProteinProtein SST2
- GeneSST2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids698 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.
Miscellaneous
Present with 5980 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | GTPase activator activity | |
Biological Process | cellular response to pheromone | |
Biological Process | conjugation with cellular fusion | |
Biological Process | intracellular signal transduction | |
Biological Process | negative regulation of signal transduction | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein SST2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP11972
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000204173 | 1-698 | Protein SST2 | ||
Modified residue | 252 | Phosphoserine | |||
Modified residue | 408 | Phosphoserine | |||
Modified residue | 539 | Phosphoserine; by MAPK | |||
Modified residue | 587 | Phosphoserine | |||
Post-translational modification
Phosphorylated by FUS3 and KSS1.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
By exposure to pheromone.
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P11972 | GPA1 P08539 | 3 | EBI-18232, EBI-7376 | |
XENO | P11972 | STE2 P0CI39 | 4 | EBI-18232, EBI-18360 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 10-203 | Fungal-DR | |||
Domain | 273-358 | DEP | |||
Domain | 420-689 | RGS | |||
Region | 545-586 | Disordered | |||
Compositional bias | 552-572 | Polar residues | |||
Domain
The fungal-differentiation regulator (Fungal-DR) domain is only found in fungal regulator of G-protein signaling (RGS) proteins that regulate differentiation pathways. It is required for function (By similarity).
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length698
- Mass (Da)79,716
- Last updated2002-04-16 v2
- MD5 ChecksumC79F6C8A570F1752991AE7343EFDDFBA
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 552-572 | Polar residues | |||
Sequence conflict | 616 | in Ref. 1; AAA35104 | |||
Sequence conflict | 644 | in Ref. 1; AAA35104 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M18105 EMBL· GenBank· DDBJ | AAA35104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U22382 EMBL· GenBank· DDBJ | AAB67534.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006945 EMBL· GenBank· DDBJ | DAA09752.1 EMBL· GenBank· DDBJ | Genomic DNA |