P0DN68 · LEXA_FIBSS
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids217 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probably represses a number of genes involved in the response to DNA damage (SOS response), including itself, recA, uvrA, ruvAB and ssb (PubMed:15528664).
The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664).
In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable)
The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664).
In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable)
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 35-55 | H-T-H motif | |||
Site | 101-102 | Cleavage; by autolysis | |||
Active site | 137 | For autocatalytic cleavage activity | |||
Active site | 174 | For autocatalytic cleavage activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | protein-DNA complex | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Fibrobacterota > Fibrobacteria > Fibrobacterales > Fibrobacteraceae > Fibrobacter
Accessions
- Primary accessionP0DN68
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000435132 | 1-217 | LexA repressor | ||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length217
- Mass (Da)24,288
- Last updated2015-12-09 v1
- ChecksumC831385424BD34FF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002158 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |