P0DN68 · LEXA_FIBSS

Function

function

Probably represses a number of genes involved in the response to DNA damage (SOS response), including itself, recA, uvrA, ruvAB and ssb (PubMed:15528664).
The probable consensus LexA box is 5'-TGCAC-N4-GTGCA-3' (PubMed:15528664).
In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (Probable)

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

121720406080100120140160180200
Type
IDPosition(s)Description
DNA binding35-55H-T-H motif
Site101-102Cleavage; by autolysis
Active site137For autocatalytic cleavage activity
Active site174For autocatalytic cleavage activity

GO annotations

AspectTerm
Cellular Componentprotein-DNA complex
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • Ordered locus names
      FSU_0077

Organism names

Accessions

  • Primary accession
    P0DN68

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004351321-217LexA repressor

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    217
  • Mass (Da)
    24,288
  • Last updated
    2015-12-09 v1
  • Checksum
    C831385424BD34FF
MENTNEKRKEMTARQEEIYEYIKKYSKENHMPPTVREIGNHFDISSTNGVRSILAALIKKGYINRSPRLSRGIEILSDDKESSKEVASNTIEIPIVGRVAAGTPILAVQNLEGTVTIDRDFLACRSDVFALRVKGDSMINAGIFDGDLIFARQQKTADLGEIVVAQIDNEATVKYYHPSADHVELRPANPKYKPIIVNNRKDFSIAGRVIGVMRKVN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002158
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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