P0CI39 · STE2_YEASX

Function

function

Receptor for the peptide pheromone alpha factor, the mating factor of yeast.

Miscellaneous

N-glycosylation may be involved in the sorting process for misfolded STE2 protein.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentG protein-coupled receptor homodimeric complex
Molecular Functionmating-type factor pheromone receptor activity
Molecular Functionpheromone binding
Biological Processpheromone-dependent signal transduction involved in conjugation with cellular fusion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pheromone alpha factor receptor

Gene names

    • Name
      STE2

Organism names

  • Taxonomic identifier
  • Strains
    • CBS 5287 / CLIB 219
    • CLIB 388
    • CLIB 410
    • CLIB 413
    • CLIB 556
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces

Accessions

  • Primary accession
    P0CI39
  • Secondary accessions
    • P06842
    • Q70D63
    • Q70D65
    • Q70D69
    • Q70D73
    • Q70D74

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-73Helical
Transmembrane80-102Helical
Transmembrane133-155Helical
Transmembrane162-184Helical
Transmembrane209-231Helical
Transmembrane244-266Helical
Transmembrane276-298Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant34in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17
Natural variant176in strain: CLIB 95, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17
Natural variant201in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17
Natural variant294in strain: CLIB 630 haplotype Ha2
Natural variant337in strain: CLIB 388, YIIc12 haplotype Ha2 and YIIc17 haplotype Ha2
Natural variant370in strain: CLIB 95, CLIB 219, CLIB 382, CLIB 388, CLIB 556, CLIB 630, K1, R12, R13, YIIc12 and YIIc17
Natural variant394in strain: R12 haplotype Ha2

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 7 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue, cross-link.

Type
IDPosition(s)Description
ChainPRO_00004023831-431Pheromone alpha factor receptor
Glycosylation25N-linked (GlcNAc...) asparagine
Glycosylation32N-linked (GlcNAc...) asparagine
Modified residue310Phosphoserine
Modified residue315Phosphoserine
Modified residue329Phosphothreonine
Modified residue331Phosphoserine
Modified residue360Phosphoserine
Modified residue363Phosphothreonine
Modified residue366Phosphoserine
Cross-link374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue382Phosphothreonine
Modified residue385Phosphoserine
Modified residue386Phosphoserine
Cross-link400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue411Phosphothreonine
Modified residue414Phosphothreonine
Cross-link422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
XENO P0CI39SST2 P119724EBI-18360, EBI-18232

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region379-406Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    47,849
  • Last updated
    2010-11-30 v1
  • Checksum
    011F604DC2A6907E
MSDAAPSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGLVNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYLLSNYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIFTGDNFKRIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYFNASTILLASSINFMSFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQSLLVPSIIFILAYSLKPNQGTDVLTTVATLLAVLSLPLSSMWATAANNASKTNTITSDFTTSTDRFYPGTLSSFQTDSINNDAKSSLRSRLYDLYPRRKETTSDKHSERTFVSETADDIEKNQFYQLPTPTSSKNTRIGPFADASYKEGEVEPVDMYTPDTAADEEARKFWTEDNNNL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ585737
EMBL· GenBank· DDBJ
CAE52257.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585738
EMBL· GenBank· DDBJ
CAE52258.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585739
EMBL· GenBank· DDBJ
CAE52259.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585740
EMBL· GenBank· DDBJ
CAE52260.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585741
EMBL· GenBank· DDBJ
CAE52261.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585742
EMBL· GenBank· DDBJ
CAE52262.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585743
EMBL· GenBank· DDBJ
CAE52263.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585744
EMBL· GenBank· DDBJ
CAE52264.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585745
EMBL· GenBank· DDBJ
CAE52265.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585746
EMBL· GenBank· DDBJ
CAE52266.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585747
EMBL· GenBank· DDBJ
CAE52267.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585748
EMBL· GenBank· DDBJ
CAE52268.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585749
EMBL· GenBank· DDBJ
CAE52269.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585750
EMBL· GenBank· DDBJ
CAE52270.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585751
EMBL· GenBank· DDBJ
CAE52271.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585752
EMBL· GenBank· DDBJ
CAE52272.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585753
EMBL· GenBank· DDBJ
CAE52273.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ585754
EMBL· GenBank· DDBJ
CAE52274.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help