O87876 · BCRA_THAAR

  • Protein
    Benzoyl-CoA reductase subunit A
  • Gene
    bcrA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the anaerobic reduction of benzoyl-CoA and 3-hydroxybenzoyl-CoA to form cyclohexa-1,5-diene-1-carbonyl-CoA and 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA, respectively. The enzyme also reduces other benzoyl-CoA analogs with small substituents at the aromatic ring.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: The iron-sulfur cluster may be a [4Fe-4S] cluster.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
15 μMbenzoyl-CoA
20 μM3-hydroxybenzoyl-CoA
600 μMATP

pH Dependence

Optimum pH is 7.2-7.5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site298[4Fe-4S] cluster (UniProtKB | ChEBI); ligand shared with BcrD
Binding site337[4Fe-4S] cluster (UniProtKB | ChEBI); ligand shared with BcrD

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionATP binding
Molecular Functionbenzoyl-CoA reductase activity
Molecular Functionmetal ion binding
Biological Processcatabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Benzoyl-CoA reductase subunit A
  • EC number
  • Alternative names
    • 3-hydroxybenzoyl-CoA reductase subunit alpha (EC:1.3.99.n1
      ) . EC:1.3.99.n1 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      bcrA

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 6984 / CIP 107765 / K172
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Rhodocyclales > Zoogloeaceae > Thauera

Accessions

  • Primary accession
    O87876

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003507301-438Benzoyl-CoA reductase subunit A

Interaction

Subunit

Heterotetramer composed of A, B, C, and D subunits.

Structure

Family & Domains

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    48,359
  • Last updated
    1998-11-01 v1
  • Checksum
    8F9E470FF688EAB7
MECFVGIDLGSTTTKAVVMDDKGQVLGRGITNSRSNYDTAARVSKLEAFIDARLSLIRRELDKEPAVAGRVDEIIDGLTRNFRREQFIEQLGDLEQTCVANVEGPRFAGKEKAIVGALTEVFRRLREEEADKLFAPDAQRKSDFFRDLAGSRFMQIGEEVARANGVEFDHLLHMYDKSIIEVENRPPSADMNRKFRSAMERVRGEMSSALDTAALGAPIDAALEIDMSERYVVGTGYGRVRLPFPKEHIRSEILCHGLGAHLMYPKTRTVLDIGGQDTKGIQIDDKGIVVNFQMNDRCAAGTGRYLGYVADEMNMGLHELGPLAMKSTKSIRINSTCTVFAGAELRDRLALGDKREDILAGLHRAIMLRAMSIISRSGGITDQFTFTGGVAKNEAAVKELRQLVKENYGEVQINIDPDSIYTGALGASEFARRAVVEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ224959
EMBL· GenBank· DDBJ
CAA12249.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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