M1GSM0 · M1GSM0_9TELE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Galaxiidae > Galaxiella

Accessions

  • Primary accession
    M1GSM0

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-52Helical
Transmembrane73-97Helical
Transmembrane117-140Helical
Transmembrane152-179Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-197Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    197
  • Mass (Da)
    20,871
  • Last updated
    2013-05-01 v1
  • MD5 Checksum
    F0D6ED08CD17D4154431931DACC42502
ALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAVSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue197

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC282473
EMBL· GenBank· DDBJ
AGE35072.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282474
EMBL· GenBank· DDBJ
AGE35073.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282475
EMBL· GenBank· DDBJ
AGE35074.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282476
EMBL· GenBank· DDBJ
AGE35075.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282477
EMBL· GenBank· DDBJ
AGE35076.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282478
EMBL· GenBank· DDBJ
AGE35077.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282479
EMBL· GenBank· DDBJ
AGE35078.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282480
EMBL· GenBank· DDBJ
AGE35079.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282481
EMBL· GenBank· DDBJ
AGE35080.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282482
EMBL· GenBank· DDBJ
AGE35081.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282483
EMBL· GenBank· DDBJ
AGE35082.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282484
EMBL· GenBank· DDBJ
AGE35083.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282485
EMBL· GenBank· DDBJ
AGE35084.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282486
EMBL· GenBank· DDBJ
AGE35085.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282487
EMBL· GenBank· DDBJ
AGE35086.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282488
EMBL· GenBank· DDBJ
AGE35087.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282489
EMBL· GenBank· DDBJ
AGE35088.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282490
EMBL· GenBank· DDBJ
AGE35089.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282491
EMBL· GenBank· DDBJ
AGE35090.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282492
EMBL· GenBank· DDBJ
AGE35091.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282493
EMBL· GenBank· DDBJ
AGE35092.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282494
EMBL· GenBank· DDBJ
AGE35093.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282495
EMBL· GenBank· DDBJ
AGE35094.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282496
EMBL· GenBank· DDBJ
AGE35095.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282497
EMBL· GenBank· DDBJ
AGE35096.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282498
EMBL· GenBank· DDBJ
AGE35097.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282499
EMBL· GenBank· DDBJ
AGE35098.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282500
EMBL· GenBank· DDBJ
AGE35099.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282501
EMBL· GenBank· DDBJ
AGE35100.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282502
EMBL· GenBank· DDBJ
AGE35101.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282503
EMBL· GenBank· DDBJ
AGE35102.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282504
EMBL· GenBank· DDBJ
AGE35103.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282505
EMBL· GenBank· DDBJ
AGE35104.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282506
EMBL· GenBank· DDBJ
AGE35105.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282507
EMBL· GenBank· DDBJ
AGE35106.1
EMBL· GenBank· DDBJ
Genomic DNA
KC282508
EMBL· GenBank· DDBJ
AGE35107.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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