M1GSM0 · M1GSM0_9TELE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids197 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Galaxiidae > Galaxiella
Accessions
- Primary accessionM1GSM0
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 22-52 | Helical | |||
Transmembrane | 73-97 | Helical | |||
Transmembrane | 117-140 | Helical | |||
Transmembrane | 152-179 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length197
- Mass (Da)20,871
- Last updated2013-05-01 v1
- MD5 ChecksumF0D6ED08CD17D4154431931DACC42502
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 197 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC282473 EMBL· GenBank· DDBJ | AGE35072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282474 EMBL· GenBank· DDBJ | AGE35073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282475 EMBL· GenBank· DDBJ | AGE35074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282476 EMBL· GenBank· DDBJ | AGE35075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282477 EMBL· GenBank· DDBJ | AGE35076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282478 EMBL· GenBank· DDBJ | AGE35077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282479 EMBL· GenBank· DDBJ | AGE35078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282480 EMBL· GenBank· DDBJ | AGE35079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282481 EMBL· GenBank· DDBJ | AGE35080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282482 EMBL· GenBank· DDBJ | AGE35081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282483 EMBL· GenBank· DDBJ | AGE35082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282484 EMBL· GenBank· DDBJ | AGE35083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282485 EMBL· GenBank· DDBJ | AGE35084.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282486 EMBL· GenBank· DDBJ | AGE35085.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282487 EMBL· GenBank· DDBJ | AGE35086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282488 EMBL· GenBank· DDBJ | AGE35087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282489 EMBL· GenBank· DDBJ | AGE35088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282490 EMBL· GenBank· DDBJ | AGE35089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282491 EMBL· GenBank· DDBJ | AGE35090.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282492 EMBL· GenBank· DDBJ | AGE35091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282493 EMBL· GenBank· DDBJ | AGE35092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282494 EMBL· GenBank· DDBJ | AGE35093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282495 EMBL· GenBank· DDBJ | AGE35094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282496 EMBL· GenBank· DDBJ | AGE35095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282497 EMBL· GenBank· DDBJ | AGE35096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282498 EMBL· GenBank· DDBJ | AGE35097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282499 EMBL· GenBank· DDBJ | AGE35098.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282500 EMBL· GenBank· DDBJ | AGE35099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282501 EMBL· GenBank· DDBJ | AGE35100.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282502 EMBL· GenBank· DDBJ | AGE35101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282503 EMBL· GenBank· DDBJ | AGE35102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282504 EMBL· GenBank· DDBJ | AGE35103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282505 EMBL· GenBank· DDBJ | AGE35104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282506 EMBL· GenBank· DDBJ | AGE35105.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282507 EMBL· GenBank· DDBJ | AGE35106.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC282508 EMBL· GenBank· DDBJ | AGE35107.1 EMBL· GenBank· DDBJ | Genomic DNA |