K9GL01 · K9GL01_PEND1
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids974 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | large ribosomal subunit | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | nucleobase-containing compound metabolic process | |
Biological Process | translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium
Accessions
- Primary accessionK9GL01
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-418 | Helicase ATP-binding | |||
Compositional bias | 106-132 | Basic and acidic residues | |||
Region | 106-163 | Disordered | |||
Region | 811-866 | Disordered | |||
Compositional bias | 814-828 | Polar residues | |||
Compositional bias | 832-853 | Basic residues | |||
Sequence similarities
Belongs to the universal ribosomal protein uL15 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length974
- Mass (Da)109,578
- Last updated2013-02-06 v1
- MD5 Checksum4A31994048758450E44B780DB94F0E49
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 106-132 | Basic and acidic residues | |||
Compositional bias | 814-828 | Polar residues | |||
Compositional bias | 832-853 | Basic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AKCU01000006 EMBL· GenBank· DDBJ | EKV21962.1 EMBL· GenBank· DDBJ | Genomic DNA |