K7FQ96 · K7FQ96_PELSI

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site251
Binding site252Ca2+ (UniProtKB | ChEBI)
Binding site281Ca2+ (UniProtKB | ChEBI)
Binding site283Ca2+ (UniProtKB | ChEBI)
Active site298
Binding site332Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentnuclear speck
Cellular Componentpostsynaptic cytosol
Cellular Componentprotein-containing complex
Molecular Functioncalcium ion binding
Molecular Functioncalmodulin binding
Molecular Functionenzyme binding
Molecular FunctionGTPase activator activity
Molecular Functionlamin binding
Molecular Functionphosphatidylinositol phospholipase C activity
Molecular Functionphosphatidylinositol-4,5-bisphosphate binding
Biological Processactivation of meiosis involved in egg activation
Biological Processcerebral cortex development
Biological Processfat cell differentiation
Biological ProcessG2/M transition of mitotic cell cycle
Biological Processglutamate receptor signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processinterleukin-1-mediated signaling pathway
Biological Processinterleukin-12-mediated signaling pathway
Biological Processinterleukin-15-mediated signaling pathway
Biological Procession channel modulating, G protein-coupled receptor signaling pathway
Biological Processligand-gated ion channel signaling pathway
Biological Processlipid catabolic process
Biological Processmemory
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of monocyte extravasation
Biological Processphosphatidylinositol metabolic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
Biological Processpositive regulation of acrosome reaction
Biological Processpositive regulation of CD24 production
Biological Processpositive regulation of developmental growth
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of embryonic development
Biological Processpositive regulation of G1/S transition of mitotic cell cycle
Biological Processpositive regulation of insulin secretion
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of myoblast differentiation
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processregulation of establishment of endothelial barrier
Biological Processregulation of fertilization
Biological Processregulation of G protein-coupled receptor signaling pathway
Biological Processregulation of retrograde trans-synaptic signaling by endocanabinoid
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      PLCB1

Organism names

Accessions

  • Primary accession
    K7FQ96

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region387-454Disordered
Compositional bias400-418Polar residues
Compositional bias427-442Acidic residues
Domain461-577PI-PLC Y-box
Domain577-705C2
Compositional bias755-771Basic and acidic residues
Region755-789Disordered
Compositional bias887-904Basic and acidic residues
Region887-910Disordered
Coiled coil914-942
Region987-1015Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,073
  • Mass (Da)
    122,877
  • Last updated
    2013-01-09 v1
  • MD5 Checksum
    62F5F1CD76C63DFF5FA7F445233B60FF
QDPKLREQLDAGNIGGRLENRMITVVYGPDLVNISYLNLVAFQEEIAKEWTDEVFSLATNLLAHNMSRDAFLEKAYTKLKLQVTHEGRIPLKSIYRLFSADRKRVETALEACNLPSARNDSIPQEDFTPEAYRVFLNNLCPRPEIDNIFSEFGAKSRPYLAVDQMMEFINYKQRDPRLNEILYPPMKQEQVQQLIEKYEPNNSLAKKGQISVDGFMRYLSGEENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGSSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMDPLEKYPLESGVPLPSPMDLMHKILVKNKKKSQKSADGSSKKKVAEQASNTCSDASSGFEPSSPGAGEAEIESDDDDDDDDDCKKSSMDEGTAGREAMATEEMSNLVNYVQPVKFESFEISNKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKRQLSRIYPKGTRVDSSNYMPQVFWNAGCQLVALNFQTVDLSMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTESIVDGIVANTLSVKIISGQFLSEKKIGTYVEVDMFGLPVDTRRKALKTKTSQGNAINPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVSAIRPGYHYICLRNERNQPLMLPAVFVYIDVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEAEQGDPPSEANHEPRPTPAENGLSHSTSLTTKPATQVVHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTAKYNEIQNDYLRRRAVLEKSTKRDSKKRCETGSPDHSSTIEQELAALDSEMTQKLIELKEKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQSSQLKKLKETCEKEKKELKKKMDKKRQEKITEAKTKDKNQMDEEKTEMIRSYIQEVVQYIKRLEDAQSKRQEKLVEKHKEIRQQILDEKPKSIEEQEVEEQKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias400-418Polar residues
Compositional bias427-442Acidic residues
Compositional bias755-771Basic and acidic residues
Compositional bias887-904Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCU01171819
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171820
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171821
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171822
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171823
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171824
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171825
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171826
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171827
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AGCU01171828
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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