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I3W8V6 · I3W8V6_PIG

  • Protein
    Mast/stem cell growth factor receptor
  • Gene
    KIT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for binding site, active site, site.

1972100200300400500600700800900
Type
IDPosition(s)Description
Binding site564Mg2+ (UniProtKB | ChEBI)
Binding site592-599ATP (UniProtKB | ChEBI)
Binding site619ATP (UniProtKB | ChEBI)
Binding site667-673ATP (UniProtKB | ChEBI)
Active site788Proton acceptor
Binding site792ATP (UniProtKB | ChEBI)
Binding site793Mg2+ (UniProtKB | ChEBI)
Binding site806Mg2+ (UniProtKB | ChEBI)
Site932Important for interaction with phosphotyrosine-binding proteins

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioncytokine binding
Molecular Functionmetal ion binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological ProcessFc receptor signaling pathway
Biological ProcessKit signaling pathway
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mast/stem cell growth factor receptor
  • EC number

Gene names

    • Name
      KIT

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    I3W8V6

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane521-544Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_501183654226-972Mast/stem cell growth factor receptor

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-98Ig-like
Domain212-308Ig-like
Domain585-933Protein kinase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    972
  • Mass (Da)
    109,195
  • Last updated
    2012-09-05 v1
  • MD5 Checksum
    E626236900A31D8AC407AD5CCCF9A1B4
MRGARRAWDFLFVLQLLLRVQTGSSQPSVSPEELSPPSIHPAKSELIVSAGDEIRLFCTDPGSVKWTFETLGQLSENTHAEWIVEKAEAMNTGNYTCTNEGGLSSSIYVFVRDPEKLFLVDPPLYGKEDNDALVRCPLTDPEVTNYSLTGCEGKPLPKDLTFVADPKAGITIRNVKREYHRLCLHCSANQGGKSMLSKKFTLKVRAAIRAVPVVAVSKASYLLREGEEFAVMCLIKDVSSSVDSMWIRENSQTKAQVKRNSWHQGDFNFLRQEKLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMMNTTVFVNDGEDVDLIVEYEAYPKPEHRQWIYMNRTATDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNADVNSSVTFNVYVNTKPEILTHDRLMNGMLQCVAAGFPEPTIDWYFCPGTEQRCSVPVGPVDVQIQNSSVSPFGKLVIHSSIDYSAFKHNGTVECRAYNDVGKSSAFFNFAFKEQIHAHTLFTPLLIGFVIAAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPHRENPAVDHSVRINSVGSSASSTQPLLVHEDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ839266
EMBL· GenBank· DDBJ
AFK92989.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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