I3W8V6 · I3W8V6_PIG
- ProteinMast/stem cell growth factor receptor
- GeneKIT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids972 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 564 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 592-599 | ATP (UniProtKB | ChEBI) | |||
Binding site | 619 | ATP (UniProtKB | ChEBI) | |||
Binding site | 667-673 | ATP (UniProtKB | ChEBI) | |||
Active site | 788 | Proton acceptor | |||
Binding site | 792 | ATP (UniProtKB | ChEBI) | |||
Binding site | 793 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 806 | Mg2+ (UniProtKB | ChEBI) | |||
Site | 932 | Important for interaction with phosphotyrosine-binding proteins | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | cytokine binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | Fc receptor signaling pathway | |
Biological Process | Kit signaling pathway | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMast/stem cell growth factor receptor
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionI3W8V6
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 521-544 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5011836542 | 26-972 | Mast/stem cell growth factor receptor | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 37-98 | Ig-like | |||
Domain | 212-308 | Ig-like | |||
Domain | 585-933 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length972
- Mass (Da)109,195
- Last updated2012-09-05 v1
- MD5 ChecksumE626236900A31D8AC407AD5CCCF9A1B4
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JQ839266 EMBL· GenBank· DDBJ | AFK92989.1 EMBL· GenBank· DDBJ | mRNA |