I2FUE9 · I2FUE9_USTHO
- ProteinFolylpolyglutamate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids559 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H+
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:14738 + CHEBI:29985 + CHEBI:30616 = (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n+1) RHEA-COMP:14740 + CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Cofactor
Note: A monovalent cation.
Pathway
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 113 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 186 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 214 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 349 | ATP (UniProtKB | ChEBI) | |||
Binding site | 367 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | tetrahydrofolylpolyglutamate synthase activity | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFolylpolyglutamate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Ustilaginomycetes > Ustilaginales > Ustilaginaceae > Ustilago
Accessions
- Primary accessionI2FUE9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length559
- Mass (Da)60,499
- Last updated2012-07-11 v1
- MD5 Checksum434E88E95B2E0E202F38E7CD4174D06C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAGI01000155 EMBL· GenBank· DDBJ | CCF50542.1 EMBL· GenBank· DDBJ | Genomic DNA |