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I2FUE9 · I2FUE9_USTHO

Function

function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Note: A monovalent cation.

Pathway

Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site113Mg2+ 1 (UniProtKB | ChEBI)
Binding site186Mg2+ 1 (UniProtKB | ChEBI)
Binding site214Mg2+ 1 (UniProtKB | ChEBI)
Binding site349ATP (UniProtKB | ChEBI)
Binding site367ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processone-carbon metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      UHOR_05743

Organism names

Accessions

  • Primary accession
    I2FUE9

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    559
  • Mass (Da)
    60,499
  • Last updated
    2012-07-11 v1
  • MD5 Checksum
    434E88E95B2E0E202F38E7CD4174D06C
MSQAQGSQPESSSAAASRTYDDAIGALNSLQSNAATIEALRKSGGRLLDFAIPEMVEYLERIGYNTSDLDRLNVIHITGTKGKGSTSAFVDSLLRQLTHVQASSPPKVGLYTSPHMTSVRERIRINGQPVSHELFTKYFWQVWDRLEENPTRKFDLTPLRPVYFRFLTLLAFHIFLSEGVQPVILEVGIGGKYDSTNIVPKCVVAGITQLGLDHTAVLGNTVEEIAVQKAGIFKPQAPAVCWAQQPGKALDEVKRIAKEVDVSDLTIVDIHPGLLRSEATALGTEDAKTVSLGLPGVHQRTNASVALELVNVYLESEAGRAMFKGSASRADALADWQKKGLEDARWPGRCQTVPTARKDLVLTWYLDGAHTTDSLSVCLGWFTAIQQKHAAEKRNKRIFVFNCTNGRSVHELLSAVLDAVEKGLGGDSASTSDGSKYALAKDYFDVAIFTTNITFEGGGWSSELTSKLLDDSDLVNLTVQKQLAETWKELVPGSSTEVKITPSIQAMHNHVVKIGGEQVKAGAGVDCLVSGSLHLVGGVMAHLQQSGCLDDSLVSTVRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAGI01000155
EMBL· GenBank· DDBJ
CCF50542.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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